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Pulmonary Cell NewsK17 occurs in the nucleus of human and mouse tumor keratinocytes where it impacts chromatin architecture, gene expression, and cell proliferation. Scientists reported that K17 is induced following DNA damage and promotes keratinocyte survival.
[Proceedings of the National Academy of Sciences of the United States of America]
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Nair, R. R., Hsu, J., Jacob, J. T., Pineda, C. M., Hobbs, R. P., & Coulombe, P. A. (2021). A role for keratin 17 during DNA damage response and tumor initiation. Proceedings of the National Academy of Sciences, 118(13). https://doi.org/10.1073/pnas.2020150118 Cite
