53BP1

[Cell Cycle] Scientists demonstrated that chrysin impaired genomic stability in MCF-7 and BT474 cells, inhibited cell survival and enhanced the sensitivity of MCF-7 cells to chemotherapeutic drugs.

[Blood] Scientists reported that CUX1 had a critical early role in the DNA repair process in hematopoietic stem and progenitor cells. Mechanistically, CUX1 recruited the histone methyltransferase EHMT2 to DNA breaks to promote downstream H3K9 and H3K27 methylation, phosphorylated ATM retention, subsequent γH2AX focus formation and propagation, and, ultimately, 53BP1 recruitment.

[Nature Communications] Scientists used centrosomes, that organize the mitotic spindle, to test whether cell division orientation and stratification are linked.

[npj Aging and Mechanisms of Disease] The Scientists investigated histone variant H2A.J as a new biomarker to detect senescent cells during human skin aging.

[Proceedings of the National Academy of Sciences of the United States of America] K17 occurs in the nucleus of human and mouse tumor keratinocytes where it impacts chromatin architecture, gene expression, and cell proliferation. Scientists reported that K17 is induced following DNA damage and promotes keratinocyte survival.

[Toxicology in Vitro] Investigators investigated DNA double-strand break and apoptosis induced by hyperthermia (HT). Umbilical cord blood lymphocytes were subjected to HT at 43 °C.