Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell NewsThe level of Dynlt3 is dependent on β-catenin activity, revealing a function of the Wnt/β-catenin signaling pathway during melanocyte and skin pigmentation, by coupling the transport, positioning and acidity of melanosomes required for their transfer.
[Communications Biology]
6445212 NJ8QP94K items 1 apa 0 default asc 1 160615 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-13e61ee8e3a55ede30bc701f2614abd5%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22NJ8QP94K%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Aktary%20et%20al.%22%2C%22parsedDate%22%3A%222021-03-26%22%2C%22numChildren%22%3A2%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EAktary%2C%20Z.%2C%20Conde-Perez%2C%20A.%2C%20Rambow%2C%20F.%2C%20Di%20Marco%2C%20M.%2C%20Amblard%2C%20F.%2C%20Hurbain%2C%20I.%2C%20Raposo%2C%20G.%2C%20Delevoye%2C%20C.%2C%20Coscoy%2C%20S.%2C%20%26amp%3B%20Larue%2C%20L.%20%282021%29.%20A%20role%20for%20Dynlt3%20in%20melanosome%20movement%2C%20distribution%2C%20acidity%20and%20transfer.%20%3Ci%3ECommunications%20Biology%3C%5C%2Fi%3E%2C%20%3Ci%3E4%3C%5C%2Fi%3E%281%29%2C%201%26%23x2013%3B15.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-021-01917-5%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.1038%5C%2Fs42003-021-01917-5%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DNJ8QP94K%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22A%20role%20for%20Dynlt3%20in%20melanosome%20movement%2C%20distribution%2C%20acidity%20and%20transfer%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Zackie%22%2C%22lastName%22%3A%22Aktary%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Alejandro%22%2C%22lastName%22%3A%22Conde-Perez%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Florian%22%2C%22lastName%22%3A%22Rambow%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Mathilde%22%2C%22lastName%22%3A%22Di%20Marco%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Fran%5Cu00e7ois%22%2C%22lastName%22%3A%22Amblard%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Ilse%22%2C%22lastName%22%3A%22Hurbain%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Gra%5Cu00e7a%22%2C%22lastName%22%3A%22Raposo%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22C%5Cu00e9dric%22%2C%22lastName%22%3A%22Delevoye%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Sylvie%22%2C%22lastName%22%3A%22Coscoy%22%7D%2C%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Lionel%22%2C%22lastName%22%3A%22Larue%22%7D%5D%2C%22abstractNote%22%3A%22Skin%20pigmentation%20is%20dependent%20on%20cellular%20processes%20including%20melanosome%20biogenesis%2C%20transport%2C%20maturation%20and%20transfer%20to%20keratinocytes.%20However%2C%20how%20the%20cells%20finely%20control%20these%20processes%20in%20space%20and%20time%20to%20ensure%20proper%20pigmentation%20remains%20unclear.%20Here%2C%20we%20show%20that%20a%20component%20of%20the%20cytoplasmic%20dynein%20complex%2C%20Dynlt3%2C%20is%20required%20for%20efficient%20melanosome%20transport%2C%20acidity%20and%20transfer.%20In%20Mus%20musculus%20melanocytes%20with%20decreased%20levels%20of%20Dynlt3%2C%20pigmented%20melanosomes%20undergo%20a%20more%20directional%20motion%2C%20leading%20to%20their%20peripheral%20location%20in%20the%20cell.%20Stage%20IV%20melanosomes%20are%20more%20acidic%2C%20but%20still%20heavily%20pigmented%2C%20resulting%20in%20a%20less%20efficient%20melanosome%20transfer.%20Finally%2C%20the%20level%20of%20Dynlt3%20is%20dependent%20on%20%5Cu03b2-catenin%20activity%2C%20revealing%20a%20function%20of%20the%20Wnt%5C%2F%5Cu03b2-catenin%20signalling%20pathway%20during%20melanocyte%20and%20skin%20pigmentation%2C%20by%20coupling%20the%20transport%2C%20positioning%20and%20acidity%20of%20melanosomes%20required%20for%20their%20transfer.%22%2C%22date%22%3A%222021-03-26%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.1038%5C%2Fs42003-021-01917-5%22%2C%22ISSN%22%3A%222399-3642%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.nature.com%5C%2Farticles%5C%2Fs42003-021-01917-5%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-03-26T22%3A42%3A53Z%22%7D%7D%5D%7D
Aktary, Z., Conde-Perez, A., Rambow, F., Di Marco, M., Amblard, F., Hurbain, I., Raposo, G., Delevoye, C., Coscoy, S., & Larue, L. (2021). A role for Dynlt3 in melanosome movement, distribution, acidity and transfer. Communications Biology, 4(1), 1–15. https://doi.org/10.1038/s42003-021-01917-5 Cite
