leukemia

[Leukemia] To interrogate the effect of protein expression alterations in AML, researchers performed a quantitative mass spectrometry in parallel with RNAseq analysis using AML mouse models.

[Scientific Reports] In a co-culture system of human umbilical vein endothelial cells and acute lymphoblastic leukemia (ALL) cells, serine protease inhibitor Kazal type 1 (SPINK1) exposure resulted in enhanced endothelial cell motility and ALL cells trans-endothelial migration.

[Leukemia] Secondary transplantation from PDX and ΔPTEN models of T-cell acute lymphoblastic leukemia (T-ALL), confirmed delayed leukemia development and extended survival of mice engrafted with T-ALL from ARV-825 treated mice, providing functional confirmation of depletion of leukemia-initiating cells.

[European Journal of Pharmacology] The authors discuss how aberrant expression of C-X-C motif chemokine 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) and CXCL12/CXCR7 pathways might regulate leukemogenesis and end by outlining the key news of preclinical and clinical investigations in leukemia treatment.

[Chemical Society Reviews] Scientists discuss available FDA-approved anti-leukemia drugs and therapies with a focus on the advances in the development of anti-leukemia drug delivery systems.

[Haematologica] Researchers designed a CD34/CD3 bispecific T-cell engager (BiTE) and characterized its anti-leukemia potential in vitro, ex vivo and in vivo.