Leukemic Progenitor Cells Enable Immunosuppression and Post-Chemotherapy Relapse via IL-36–Inflammatory Monocyte Axis

Researchers showed that abnormal IL-36 production activated by NF-κB was an essential feature of mouse and human leukemic progenitor cells.
[Science Advances]
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p300 Suppresses the Transition of Myelodysplastic Syndromes to Acute Myeloid Leukemia

Scientists identified a tumor suppressor role of the acetyltransferase p300 in clinically relevant myelodysplastic syndromes models driven by mutations in the epigenetic regulators TET2, ASXL1, and SRSF2.
[JCI Insight]
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Gates Biomanufacturing Facility Announces Strategic Manufacturing Partnership with Cell Therapy Pioneer, Nkarta

The Gates Biomanufacturing Facility signed a continued strategic agreement with Nkarta to manufacture clinical supply of therapeutic Natural Killer cells. As part of this collaboration, GBF will continue to manufacture NKX101, an immunotherapy currently in a Phase I clinical trial for patients with relapsed/refractory acute myeloid leukemia or higher-risk myelodysplastic syndromes.
[Gates Biomanufacturing Facility]
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Sutro Biopharma and BioNova Pharmaceuticals Enter into Collaboration for STRO-001 in Greater China

Sutro Biopharma, Inc and BioNova Pharmaceuticals Limited announced an option agreement for BioNova to develop and commercialize STRO-001, a CD74-targeting Antibody-Drug Conjugate, for patients with hematologic cancers, in Greater China, including mainland China, Hong Kong, Macau and Taiwan.
[Sutro Biopharma, Inc.]
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CAR-T Cell Therapy in T Cell Malignancies: Is Success a Low-Hanging Fruit?

Investigators highlight the preclinical and clinical efforts made for addressing these drawbacks and also review additional potent stratagems that could improve CAR-T therapy in T cell malignancies.
[Stem Cell Research & Therapy]
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Emerging Approaches to Improve Allogeneic Hematopoietic Cell Transplantation Outcomes for Non-malignant Diseases

Scientists discuss the current approach to each of these clinical issues and how emerging novel therapeutics hold promise to advance transplant care for patients with non-malignant diseases.
[Blood]
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Cytoplasmic NEAT1 Suppresses AML Stem Cell Self-Renewal and Leukemogenesis through Inactivation of Wnt Signaling

The authors reported an adverse effect of NEAT1, showing that the short isoform, NEAT1_1 suppressed acute myeloid leukemia (AML) development. NEAT1_1 was downregulated in leukemia stem cells and its decreased expression correlated with recurrence in AML patients.
[Advanced Science]
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Advances in Acute Myeloid Leukemia

Investigators discuss important updates in diagnostic and disease classifications that reflect new understanding of the biology of acute myeloid leukemia, its mutational heterogeneity, some important genetic and environmental risk factors, and new treatment options including cytotoxic chemotherapy, novel targeted agents, and cellular therapies.
[Bmj Open]
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Aberrantly Reduced Expression of miR-342-5p Contributes to CCND1-Associated Chronic Myeloid Leukemia Progression and Imatinib Resistance

Scientists used next-generation sequencing to explore endogenous miRNAs in chronic myeloid leukemia (CML) patients versus healthy volunteers, and miR-342-5p was identified as the primary target. They found that miR-342-5p was downregulated in CML patients and had a significant inhibitory effect on cell proliferation in CML.
[Cell Death & Disease]
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ULK1 Inhibition Promotes Oxidative Stress–Induced Differentiation and Sensitizes Leukemic Stem Cells to Targeted Therapy

The authors showed that deletion of autophagy-inducing kinase unc-51–like autophagy activating kinase 1 (ULK1) reduced growth of cell line and patient-derived xenografted chronic myeloid leukemia cells in mouse models.
[Science Translational Medicine]
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A Selective WDR5 Degrader Inhibits Acute Myeloid Leukemia in Patient-Derived Mouse Models

MS67 potently and selectively depleted WD40 repeat domain protein 5 (WDR5) and was more effective than WDR5 protein-protein interactions inhibitors in suppressing transcription of WDR5-regulated genes, decreasing the chromatin-bound fraction of mixed lineage leukemia complex components and c-MYC, and inhibiting the proliferation of cancer cells.
[Science Translational Medicine]
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