leukemia

[Nature Communications] Scientists showed single-cell T cell receptor (TCR) coupled with RNA sequencing of CD3+ T cells from 13 patients, sampled before and after alemtuzumab treatments. Effector memory T cells and loss of TCR repertoire diversity were prevalent in T cell large granular lymphocyte leukemia.

[Nature Communications] Utilizing single-cell RNA and T cell receptor profiling, researchers showed that irrespective of STAT3 mutation status, T cell large granular lymphocytic leukemia clonotypes were more cytotoxic and exhausted than healthy reactive clonotypes.

[Nature Communications] Scientists showed single-cell T cell receptor (TCR) coupled with RNA sequencing of CD3+ T cells from 13 patients, sampled before and after alemtuzumab treatments. Effector memory T cells and loss of TCR repertoire diversity were prevalent in T cell large granular lymphocyte leukemia.

[Twist Bioscience Corporation] Twist Bioscience Corporation and MediSix Therapeutics announced a collaboration to discover novel antibodies against five undisclosed targets. Twist will leverage its proprietary Library of Libraries to discover five novel antibodies directed against MediSix’s targets.

[Leukemia] Researchers provide a rationale for the clinical development of fadraciclib in chronic lymphocytic leukemia, either alone or in combination with a Bcl-2 antagonist.

[Haematologica] Scientists investigated the oncogenic function of TAL1 and the possible cooperation with PI3K-AKT pathway activation using isogenic pro-T cell cultures ex vivo and in vivo leukemia models.