leukemia

[Nature Communications] The authors used a comprehensive panel of in vitro and in vivo assays to demonstrate that CX-5461 had been mischaracterized and that its primary target at pharmacologically relevant concentrations was topoisomerase II beta (TOP2B).

[Scientific Reports] The genomic regions ranging from 500 base pairs upstream to 500 base pairs downstream of the eight SNPs that were reported as transplantation determinants by Petersdorf et al. were analyzed to evaluate whether genetic variants were associated with the survival status of patient

[Scientific Reports] Scientists revealed that three SNPs located in the intron or 3’-UTR of HLA-DOB regions are associated with the survival of patients in the recipient and donor-recipient matching groups, as well as cytomegalovirus infection/reactivation in the donor-recipient matching group.

[Nature Communications] Investigators indicated that 5′-Azacitidine increased the immunogenicity of acute myeloid leukemia cells, enhancing recognition and elimination of malignant cells by highly efficient CTLA-4negative anti-CD123 chimeric antigen receptor (CAR) T cells.

[Cell Death & Disease] Scientists discovered that the T-complex protein 1 (TCP1) expression was elevated in acute myeloid leukemia patients and high TCP1 expression was associated with low complete response rate along with poor overall survival.

[Leukemia] Investigators found that CD109 suppressed TGF-β signaling in hematopoietic stem progenitor cells (HSPCs), and increased the sensitivity of PIGA-mutated HSPCs to TGF-β, leading to the preferential commitment of erythroid progenitor cells to mature red blood cells in immune-mediated bone marrow failure.