Demethylating Therapy Increases Anti-CD123 CAR T Cell Cytotoxicity against Acute Myeloid Leukemia

Investigators indicated that 5′-Azacitidine increased the immunogenicity of acute myeloid leukemia cells, enhancing recognition and elimination of malignant cells by highly efficient CTLA-4negative anti-CD123 chimeric antigen receptor (CAR) T cells.