leukocytes

[Nature Communications] Researchers reported PD-1 signaling regulated the initial T cell receptor antigen recognition manifested in a smaller spreading area, fewer molecular bonds formed, and shorter bond lifetime of T cell interaction with peptide-major histocompatibility complex in the presence than absence of PD-1 ligand-1 in a manner dependent on Src homology region 2 domain-containing phosphatases and Leukocyte C-terminal Src kinase.

[Nature Communications] Researchers engineered red blood cells into artificial antigen-presenting cells presenting a peptide bound to the major histocompatibility complex I, the costimulatory ligand 4-1BBL, and interleukin-12.

[International Journal of Molecular Sciences] The author details the immune cell subsets in afferent and efferent lymph, and explores the mechanisms by which endothelial cells of the lymphatic system regulate such trafficking, for immune surveillance and tolerance during steady-state conditions, and in response to infection, acute and chronic inflammation, and subsequent resolution.

[PLoS One] Investigators serially characterized leukocyte populations in colostrum for differential leukocyte counts. Differences in humoral and cellular composition of colostrum between 40 gilts and 40 sows from a commercial herd were examined.

[Journal of Hematology & Oncology] Scientists compared the allogeneic hematopoietic cell transplantation (allo-HCT) outcomes of cord blood transplantation versus single-allele-mismatched mismatched unrelated donor allo-HCT with post-transplant cyclophosphamide in acute myeloid leukemia.

[Nature Reviews Cancer] Scientists discuss the key molecular processes that facilitate metastasis in a variety of leukemic subtypes, the clinical significance of leukemic invasion into specific tissues and the current pipeline of treatments targeting leukemia metastasis.