The author details the immune cell subsets in afferent and efferent lymph, and explores the mechanisms by which endothelial cells of the lymphatic system regulate such trafficking, for immune surveillance and tolerance during steady-state conditions, and in response to infection, acute and chronic inflammation, and subsequent resolution.
[International Journal of Molecular Sciences]
6445212 KANB96F7 items 1 apa 0 default asc 1 162006 https://www.stemcellsciencenews.com/wp-content/plugins/zotpress/
%7B%22status%22%3A%22success%22%2C%22updateneeded%22%3Afalse%2C%22instance%22%3A%22zotpress-ab24e38878c77ad1a8be4ff60cc0dd70%22%2C%22meta%22%3A%7B%22request_last%22%3A0%2C%22request_next%22%3A0%2C%22used_cache%22%3Atrue%7D%2C%22data%22%3A%5B%7B%22key%22%3A%22KANB96F7%22%2C%22library%22%3A%7B%22id%22%3A6445212%7D%2C%22meta%22%3A%7B%22creatorSummary%22%3A%22Johnson%22%2C%22parsedDate%22%3A%222021-01%22%2C%22numChildren%22%3A1%7D%2C%22bib%22%3A%22%3Cdiv%20class%3D%5C%22csl-bib-body%5C%22%20style%3D%5C%22line-height%3A%202%3B%20padding-left%3A%201em%3B%20text-indent%3A-1em%3B%5C%22%3E%5Cn%20%20%3Cdiv%20class%3D%5C%22csl-entry%5C%22%3EJohnson%2C%20L.%20A.%20%282021%29.%20In%20Sickness%20and%20in%20Health%3A%20The%20Immunological%20Roles%20of%20the%20Lymphatic%20System.%20%3Ci%3EInternational%20Journal%20of%20Molecular%20Sciences%3C%5C%2Fi%3E%2C%20%3Ci%3E22%3C%5C%2Fi%3E%289%29%2C%204458.%20%3Ca%20href%3D%27https%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijms22094458%27%3Ehttps%3A%5C%2F%5C%2Fdoi.org%5C%2F10.3390%5C%2Fijms22094458%3C%5C%2Fa%3E%20%3Ca%20title%3D%27Cite%20in%20RIS%20Format%27%20class%3D%27zp-CiteRIS%27%20href%3D%27https%3A%5C%2F%5C%2Fwww.stemcellsciencenews.com%5C%2Fwp-content%5C%2Fplugins%5C%2Fzotpress%5C%2Flib%5C%2Frequest%5C%2Frequest.cite.php%3Fapi_user_id%3D6445212%26amp%3Bitem_key%3DKANB96F7%27%3ECite%3C%5C%2Fa%3E%20%3C%5C%2Fdiv%3E%5Cn%3C%5C%2Fdiv%3E%22%2C%22data%22%3A%7B%22itemType%22%3A%22journalArticle%22%2C%22title%22%3A%22In%20Sickness%20and%20in%20Health%3A%20The%20Immunological%20Roles%20of%20the%20Lymphatic%20System%22%2C%22creators%22%3A%5B%7B%22creatorType%22%3A%22author%22%2C%22firstName%22%3A%22Louise%20A.%22%2C%22lastName%22%3A%22Johnson%22%7D%5D%2C%22abstractNote%22%3A%22The%20lymphatic%20system%20plays%20crucial%20roles%20in%20immunity%20far%20beyond%20those%20of%20simply%20providing%20conduits%20for%20leukocytes%20and%20antigens%20in%20lymph%20fluid.%20Endothelial%20cells%20within%20this%20vasculature%20are%20distinct%20and%20highly%20specialized%20to%20perform%20roles%20based%20upon%20their%20location.%20Afferent%20lymphatic%20capillaries%20have%20unique%20intercellular%20junctions%20for%20efficient%20uptake%20of%20fluid%20and%20macromolecules%2C%20while%20expressing%20chemotactic%20and%20adhesion%20molecules%20that%20permit%20selective%20trafficking%20of%20specific%20immune%20cell%20subsets.%20Moreover%2C%20in%20response%20to%20events%20within%20peripheral%20tissue%20such%20as%20inflammation%20or%20infection%2C%20soluble%20factors%20from%20lymphatic%20endothelial%20cells%20exert%20%5Cu201cremote%20control%5Cu201d%20to%20modulate%20leukocyte%20migration%20across%20high%20endothelial%20venules%20from%20the%20blood%20to%20lymph%20nodes%20draining%20the%20tissue.%20These%20immune%20hubs%20are%20highly%20organized%20and%20perfectly%20arrayed%20to%20survey%20antigens%20from%20peripheral%20tissue%20while%20optimizing%20encounters%20between%20antigen-presenting%20cells%20and%20cognate%20lymphocytes.%20Furthermore%2C%20subsets%20of%20lymphatic%20endothelial%20cells%20exhibit%20differences%20in%20gene%20expression%20relating%20to%20specific%20functions%20and%20locality%20within%20the%20lymph%20node%2C%20facilitating%20both%20innate%20and%20acquired%20immune%20responses%20through%20antigen%20presentation%2C%20lymph%20node%20remodeling%20and%20regulation%20of%20leukocyte%20entry%20and%20exit.%20This%20review%20details%20the%20immune%20cell%20subsets%20in%20afferent%20and%20efferent%20lymph%2C%20and%20explores%20the%20mechanisms%20by%20which%20endothelial%20cells%20of%20the%20lymphatic%20system%20regulate%20such%20trafficking%2C%20for%20immune%20surveillance%20and%20tolerance%20during%20steady-state%20conditions%2C%20and%20in%20response%20to%20infection%2C%20acute%20and%20chronic%20inflammation%2C%20and%20subsequent%20resolution.%22%2C%22date%22%3A%222021%5C%2F1%22%2C%22language%22%3A%22en%22%2C%22DOI%22%3A%2210.3390%5C%2Fijms22094458%22%2C%22ISSN%22%3A%22%22%2C%22url%22%3A%22https%3A%5C%2F%5C%2Fwww.mdpi.com%5C%2F1422-0067%5C%2F22%5C%2F9%5C%2F4458%22%2C%22collections%22%3A%5B%5D%2C%22dateModified%22%3A%222021-05-07T18%3A44%3A47Z%22%7D%7D%5D%7D
Johnson, L. A. (2021). In Sickness and in Health: The Immunological Roles of the Lymphatic System. International Journal of Molecular Sciences, 22(9), 4458. https://doi.org/10.3390/ijms22094458 Cite