Healthy versus Inflamed Lung Environments Differentially Affect Mesenchymal Stromal Cells

Scientists comparatively assessed how the inflammatory environment present in acute respiratory distress syndrome lungs versus the lung environment present in healthy volunteers alters MSC behavior.
[European Respiratory Journal]
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Adoptive CD8+T-Cell Grafted with Liposomal Immunotherapy Drugs to Counteract the Immune Suppressive Tumor Microenvironment and Enhance Therapy for Melanoma

The immunosuppressive tumor microenvironment has become a formidable obstacle to the treatment of tumors using adoptive T cell therapy, in particular solid tumors. Effector OT-1 CD8+T cells conjugated with liposomal immune regulators were developed to address this issue.
[Nanoscale]
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Immune-Onc Therapeutics Announces First Patient Dosed in Phase 1 Clinical Trial Evaluating IO-108, a Novel Antagonist Antibody Targeting LILRB2 (ILT4), in Patients with Advanced Solid Tumors

Immune-Onc Therapeutics, Inc. announced that the first patient has been dosed in the company’s first-in-human clinical trial of IO-108, a novel antagonist antibody targeting the myeloid checkpoint Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) for the treatment of solid tumors.
[Immune-Onc Therapeutics, Inc.]
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Biomarkers of Response to Checkpoint Inhibitors beyond PD-L1 in Lung Cancer

In this review, scientists address the state of PD-L1 testing in lung cancer, the role for tumor mutation burden as a predictive biomarker
[Modern Pathology]
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Regulation of the Immune Tolerance System Determines the Susceptibility to HLA-Mediated Abacavir-Induced Skin Toxicity

The authors showed the importance of immune tolerance for idiosyncratic drug toxicity (IDT) onset and determine whether it was susceptible to a common IDT, HLA-B*57:01-mediated abacavir-induced hypersensitivity, using CD4+ T cell-depleted programmed death-1 receptor-deficient HLA-B*57:01 transgenic mice
[Communications Biology]
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9p21 Loss Confers a Cold Tumor Immune Microenvironment and Primary Resistance to Immune Checkpoint Therapy

The authors demonstrated that 9p21 loss confers “cold” tumor-immune phenotypes, characterized by reduced abundance of tumor-infiltrating leukocytes, particularly, T/B/NK cells, altered spatial TILs patterns, diminished immune cell trafficking/activation, decreased rate of PD-L1 positivity, along with activation of immunosuppressive signaling.
[Nature Communications]
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The Cross Talk between Gastric Cancer Stem Cells and the Immune Microenvironment: A Tumor-Promoting Factor

Scientists provide an overview of bidirectional interactions between cancer stem cells and immune cells in gastric cancer, compiling relevant data about how CSCs can induce leukocyte reprogramming, resulting in pro-tumoral immune cells that orchestrate promotion of metastasis, chemoresistance, tumorigenicity, and even increase in number of cancer cells with stem properties.
[Stem Cell Research & Therapy]
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Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

Scientists described an anti-HLA-A2 CAR generated by grafting the complementarity-determining regions of a human monoclonal anti-HLA-A2 antibody into the framework regions of the Herceptin 4D5 single-chain variable fragment and fusing it with a CD28-ζ signaling domain.
[Frontiers in Immunology]
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Chemerin Regulates Normal Angiogenesis and Hypoxia-Driven Neovascularization

Chemerin did not affect vascular sprouting during the post-natal development of the network, but rather promoted endothelial cell apoptosis and vessel pruning.
[Angiogenesis]
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Systematic Discovery and Validation of T Cell Targets Directed against Oncogenic KRAS Mutations

The authors evaluated the presentation of mutant KRAS peptides on individual HLA-I molecules using targeted mass spectrometry and identify 13 unpublished KRASG12C/D/R/V mutation/HLA-I pairs and nine previously described pairs.
[Cell Reports Methods]
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Evaluate the Presentation of Mutant KRAS Peptides on Individual HLA-I Molecules Using Targeted Mass Spectrometry and Identify 13 Unpublished KRASG12C/D/R/V Mutation/HLA-I Pairs and Nine Previously Described Pairs.

The authors evaluated the presentation of mutant KRAS peptides on individual HLA-I molecules using targeted mass spectrometry and identify 13 unpublished KRASG12C/D/R/V mutation/HLA-I pairs and nine previously described pairs.
[Cell Reports Methods]
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