Eotaxin-1/CCL11 Is Involved in Cell Migration in Rheumatoid Arthritis

The authors investigated the expression and function of Eotaxin-1 (CCL11) in rheumatoid arthritis fibroblast-like synoviocytes.
[Scientific Reports]
Wakabayashi, K., Isozaki, T., Tsubokura, Y., Fukuse, S., & Kasama, T. (2021). Eotaxin-1/CCL11 is involved in cell migration in rheumatoid arthritis. Scientific Reports, 11(1), 7937. https://doi.org/10.1038/s41598-021-87199-7 Cite
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USP15: A Review of Its Implication in Immune and Inflammatory Processes and Tumor Progression

reviewed are recent studies of USP15 in model cell lines in vitro, and in mutant mice in vivo with reference to available human clinical datasets.
[Genes & Immunity]
Georges, A., Gros, P., & Fodil, N. (2021). USP15: a review of its implication in immune and inflammatory processes and tumor progression. Genes & Immunity, 1–12. https://doi.org/10.1038/s41435-021-00125-9 Cite
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Embryonic Stem Cell Derived Small Extracellular Vesicles Modulate Regulatory T Cells to Protect against Ischemic Stroke

Researchers determined the therapeutic function of embryonic stem cell derived extracellular vesicles, specifically focusing on their role in immunomodulation after ischemic stroke.
[ACS Nano]
Xia, Y., Hu, G., Chen, Y., Yuan, J., Zhang, J., Wang, S., Li, Q., Wang, Y., & Deng, Z. (2021). Embryonic Stem Cell Derived Small Extracellular Vesicles Modulate Regulatory T Cells to Protect against Ischemic Stroke. ACS Nano. https://doi.org/10.1021/acsnano.1c00672 Cite
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TNF-α and α-Synuclein Fibrils Differently Regulate Human Astrocyte Immune Reactivity and Impair Mitochondrial Respiration

Researchers examined the cellular changes triggered by tumor necrosis factor alpha (TNF-α) and different alpha-synuclein species in astrocytes derived from induced pluripotent stem cells.
[Cell Reports]
Russ, K., Teku, G., Bousset, L., Redeker, V., Piel, S., Savchenko, E., Pomeshchik, Y., Savistchenko, J., Stummann, T. C., Azevedo, C., Collin, A., Goldwurm, S., Fog, K., Elmer, E., Vihinen, M., Melki, R., & Roybon, L. (2021). TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration. Cell Reports, 34(12). https://doi.org/10.1016/j.celrep.2021.108895 Cite
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Predictive Analytics and Cord Blood Banking: Toward Utilization-Based Unit Selection

The authors present a multi-parameter linear regression model capable of identifying cord blood units that would process poorly, despite meeting established pre-process total nucleated cell and CD34+ quality thresholds.
[Cytotherapy]
Wynn, L. A., & Madrigal, A. (2021). Predictive analytics and cord blood banking: toward utilization-based unit selection. Cytotherapy, 0(0). https://doi.org/10.1016/j.jcyt.2021.01.002 Cite
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Graft-Derived Extracellular Vesicles Transported across Subcapsular Sinus Macrophages Elicit B Cell Alloimmunity after Transplantation

Researchers demonstrated that migration of donor leukocytes out of skin or heart allografts is not necessary for B or T cell allosensitization in mice.
[Science Translational Medicine]
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Identification of Bacteria-Derived HLA-Bound Peptides in Melanoma

Researchers used 16S rRNA gene sequencing and HLA peptidomics to identify a peptide repertoire derived from intracellular bacteria that was presented on HLA-I and HLA-II molecules in melanoma tumors.
[Nature]
Kalaora, S., Nagler, A., Nejman, D., Alon, M., Barbolin, C., Barnea, E., Ketelaars, S. L. C., Cheng, K., Vervier, K., Shental, N., Bussi, Y., Rotkopf, R., Levy, R., Benedek, G., Trabish, S., Dadosh, T., Levin-Zaidman, S., Geller, L. T., Wang, K., … Samuels, Y. (2021). Identification of bacteria-derived HLA-bound peptides in melanoma. Nature, 1–6. https://doi.org/10.1038/s41586-021-03368-8 Cite
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Antigen Presentation in Cancer: Insights into Tumor Immunogenicity and Immune Evasion

Scientists review the tumor-derived factors modulating dendritic cell function.
[Nature Reviews Cancer]
Jhunjhunwala, S., Hammer, C., & Delamarre, L. (2021). Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion. Nature Reviews Cancer, 1–15. https://doi.org/10.1038/s41568-021-00339-z Cite
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Prolactin Modifies the In Vitro LPS-Induced Chemotactic Capabilities in Human Fetal Membranes at the Term of Gestation

Fetal membranes and umbilical cord blood were collected from healthy non‐labouring cesarean deliveries at term. Fetal membranes were culture in Transwell® frames to mimic the barrier function between choriodecidual and amniotic sides.
[American Journal of Reproductive Immunology]
Núñez‐Sánchez, E., Flores‐Espinosa, P., Mancilla‐Herrera, I., González‐Ibarra, L., Cisneros, J., Olmos‐Ortiz, A., Quesada‐Reyna, B., Granados‐Cepeda, M., & Zaga‐Clavellina, V. (n.d.). Prolactin modifies the in vitro LPS-induced chemotactic capabilities in human fetal membranes at the term of gestation. American Journal of Reproductive Immunology, n/a(n/a), e13413. https://doi.org/https://doi.org/10.1111/aji.13413 Cite
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Human Leukocyte Antigen-G Upregulates Immunoglobulin-Like Transcripts and Corrects Dysfunction of Immune Cells in Immune Thrombocytopenia

Researchers observed significantly less human leukocyte antigen-G in plasma from immune thrombocytopenia patients positive for anti-platelet autoantibodies compared with autoantibodies-negative patients or healthy controls.
[Haematologica]
Li, X., Sheng, Z., Sun, Y., Wang, Y., Xu, M., Zhang, Z., Li, H., Shao, L., Zhang, Y., Yu, J., Ma, C., Gao, C., Hou, M., Ni, H., Peng, J., Ma, J., & Feng, Q. (2021). Human leukocyte antigen-G upregulates immunoglobulin-like transcripts and corrects dysfunction of immune cells in immune thrombocytopenia. Haematologica, 106(3), 770–781. https://doi.org/10.3324/haematol.2018.204040 Cite
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Bispecific Antibodies Targeting Mutant Ras Neoantigens

Using phage display, researchers isolated single-chain variable fragments specific for each mutant peptide-HLA complexes.
[Science Immunology]
Douglass, J., Hsiue, E. H.-C., Mog, B. J., Hwang, M. S., DiNapoli, S. R., Pearlman, A. H., Miller, M. S., Wright, K. M., Azurmendi, P. A., Wang, Q., Paul, S., Schaefer, A., Skora, A. D., Molin, M. D., Konig, M. F., Liu, Q., Watson, E., Li, Y., Murphy, M. B., … Zhou, S. (2021). Bispecific antibodies targeting mutant RAS neoantigens. Science Immunology, 6(57). https://doi.org/10.1126/sciimmunol.abd5515 Cite
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