A Molecular Map of Murine Lymph Node Blood Vascular Endothelium at Single Cell Resolution

The authors profiled transcriptomes of blood vascular endothelial cells from peripheral lymph nodes and map phenotypes to the vasculature.
[Nature Communications]
Brulois, K., Rajaraman, A., Szade, A., Nordling, S., Bogoslowski, A., Dermadi, D., Rahman, M., Kiefel, H., O’Hara, E., Koning, J. J., Kawashima, H., Zhou, B., Vestweber, D., Red-Horse, K., Mebius, R. E., Adams, R. H., Kubes, P., Pan, J., & Butcher, E. C. (2020). A molecular map of murine lymph node blood vascular endothelium at single cell resolution. Nature Communications, 11(1), 1–15. https://doi.org/10.1038/s41467-020-17291-5 Cite
Full Article

Continue reading “A Molecular Map of Murine Lymph Node Blood Vascular Endothelium at Single Cell Resolution”

Bookmark

No account yet? Register

0
Share

CD122-Targetted IL-2 Signals Cause Acute and Selective Apoptosis of B Cells in Peyer’s Patches

Scientists found that IL-2C targeting cells expressing IL-2 receptor beta caused an acute decrease in cellularity of Peyer’s Patches while cell numbers in the lamina propria and intraepithelial lymphocytes were unaffected.
[Scientific Reports]
Singh, A., Dhume, K., Tejero, J. D., Strutt, T. M., & McKinstry, K. K. (2020). CD122-targetted IL-2 signals cause acute and selective apoptosis of B cells in Peyer’s Patches. Scientific Reports, 10(1), 12668. https://doi.org/10.1038/s41598-020-69632-5 Cite
Full Article

Continue reading “CD122-Targetted IL-2 Signals Cause Acute and Selective Apoptosis of B Cells in Peyer’s Patches”

Bookmark

No account yet? Register

0
Share

DTI Tract‐Based Quantitative Susceptibility Mapping: An Initial Feasibility Study to Investigate the Potential Role of Myelination in Brain Connectivity Change in Cerebral Palsy Patients during Autologous Cord Blood Cell Therapy Using a Rotationally‐Invariant Quantitative Measure

A cohort of eight pediatric cereberal palsy (CP) patients with intact corticospinal tracts from a randomized, placebo‐controlled trial of autologous umbilical cord blood stem‐cell therapy in CP children was included in this study.
[Journal of Magnetic Resonance Imaging]
Abstract

Continue reading “DTI Tract‐Based Quantitative Susceptibility Mapping: An Initial Feasibility Study to Investigate the Potential Role of Myelination in Brain Connectivity Change in Cerebral Palsy Patients during Autologous Cord Blood Cell Therapy Using a Rotationally‐Invariant Quantitative Measure”

Bookmark

No account yet? Register

0
Share

Intra-Articular Xenogeneic Mesenchymal Stem Cell-Based Therapy Increases CD4+CD25+ Cells in Synovial Fluid

The authors aimed to identify the lymphocytic response to a xenogeneic human umbilical cord-derived mesenchymal stem cell-based cell therapy.
[Veterinary Immunology and Immunopathology]
Lamers, K., Baquero, M., Karrow, N., & Hurtig, M. (2020). Intra-articular xenogeneic mesenchymal stem cell-based therapy increases CD4+CD25+ cells in synovial fluid. Veterinary Immunology and Immunopathology, 227, 110085. https://doi.org/10.1016/j.vetimm.2020.110085 Cite
Abstract

Continue reading “Intra-Articular Xenogeneic Mesenchymal Stem Cell-Based Therapy Increases CD4+CD25+ Cells in Synovial Fluid”

Bookmark

No account yet? Register

0
Share

Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy

Researchers established an apoptosis inhibitor of macrophage (AIM)-deficient IgAN model using CRISPR/Cas9 and compared its phenotype with that of wild-type gddY with or without recombinant AIM administration. An IgA-deficient IgAN model was also generated to further determine the role of AIM.
[Journal of the American Society of Nephrology]
Abstract

Continue reading “Crucial Role of AIM/CD5L in the Development of Glomerular Inflammation in IgA Nephropathy”

Bookmark

No account yet? Register

0
Share

Longevity and Replenishment of Human Liver-Resident Memory T Cells and Mononuclear Phagocytes

Allografts were rapidly infiltrated by recipient leukocytes, which recapitulated the liver myeloid and lymphoid composition, and underwent partial reprogramming with acquisition of CD68/CD206 on MNPs and CD69/CD103 on T cells.
[Journal of Experimental Medicine]
AbstractGraphical Abstract

Continue reading “Longevity and Replenishment of Human Liver-Resident Memory T Cells and Mononuclear Phagocytes”

Bookmark

No account yet? Register

0
Share

Targeting Leukocidin-Mediated Immune Evasion Protects Mice from Staphylococcus aureus Bacteremia

Researchers demonstrated that infection with a leukocidin mutant results in increased levels of anti–S. aureus antibodies compared with mice infected with the WT parental strain, indicating that leukocidins negatively impacrft the generation of anti–S. aureus antibodies in vivo.
[Journal of Experimental Medicine]
Tam, K., Lacey, K. A., Devlin, J. C., Coffre, M., Sommerfield, A., Chan, R., … Torres, V. J. (2020). Targeting leukocidin-mediated immune evasion protects mice from Staphylococcus aureus bacteremia. Journal of Experimental Medicine, 217(9). https://doi.org/10.1084/jem.20190541 Cite
Full Article

Continue reading “Targeting Leukocidin-Mediated Immune Evasion Protects Mice from Staphylococcus aureus Bacteremia”

Bookmark

No account yet? Register

0
Share

HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity

In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble with a peptide and takes it to the cell surface for surveillance by lymphocytes.
[Annual Review of Biochemistry]
Djaoud, Z., & Parham, P. (2020). HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity. Annual Review of Biochemistry, 89(1), 717–739. https://doi.org/10.1146/annurev-biochem-011520-102754 Cite
Abstract

Continue reading “HLAs, TCRs, and KIRs, a Triumvirate of Human Cell-Mediated Immunity”

Bookmark

No account yet? Register

0
Share

TNF Deficiency Dysregulates Inflammatory Cytokine Production, Leading to Lung Pathology and Death during Respiratory Poxvirus Infection

Tumor necrosis factor (TNF) deficiency did not affect viral load or leukocyte recruitment but caused severe lung pathology and excessive production of the cytokines interleukin (IL)-6, IL-10, transforming growth factor beta, and interferon gamma
[Proceedings of the National Academy of Sciences of the United States of America]
Abstract

Continue reading “TNF Deficiency Dysregulates Inflammatory Cytokine Production, Leading to Lung Pathology and Death during Respiratory Poxvirus Infection”

Bookmark

No account yet? Register

0
Share

Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Nonexposed Mucosal Organs and Primes for Allergic Inflammation

Researchers investigated the impact of acute local allergen exposure on the frequency and phenotype of tissue eosinophils within remote mucosal organs.
[Mucosal Immunology]
Abstract

Continue reading “Remote Allergen Exposure Elicits Eosinophil Infiltration into Allergen Nonexposed Mucosal Organs and Primes for Allergic Inflammation”

Bookmark

No account yet? Register

0
Share

Increasing Serotonin Bioavailability Alters Gene Expression in Peripheral Leukocytes and Lymphoid Tissues of Dairy Calves

Investigators established that bovine peripheral leukocytes express all known serotonin receptors, and can synthesize, uptake and degrade serotonin due to the expression of serotonin metabolism-related genes.
[Scientific Reports]
Full Article

Continue reading “Increasing Serotonin Bioavailability Alters Gene Expression in Peripheral Leukocytes and Lymphoid Tissues of Dairy Calves”

Bookmark

No account yet? Register

0
Share

Neutrophils Preferentially Phagocytose Elongated Particles—An Opportunity for Selective Targeting in Acute Inflammatory Diseases

Scientists investigated the phagocytosis of rod-shaped polymeric particles by human neutrophils relative to other leukocytes. In contrast to macrophages and other mononuclear phagocytes, neutrophils were found to exhibit increased internalization of rods in ex vivo and in vivo experimentation.
[Science Advances]
Full Article

Continue reading “Neutrophils Preferentially Phagocytose Elongated Particles—An Opportunity for Selective Targeting in Acute Inflammatory Diseases”

Bookmark

No account yet? Register

0
Share
Share