[Journal For Immunotherapy of Cancer] Researchers supported the rational design of immunotherapeutic strategies targeting cancer stem cells to optimize their responsiveness to local CD8+CD103+ TRM cells for more efficient anticancer treatments.
[Haematologica] Scientists found IgG Fc glycosylation of anti-HLA antibodies to be highly variable between patients with platelet refractoriness, especially with respect to galactosylation and sialylation of the Fc-bound sugar moiety.
[OncoImmunology] Researchers characterized γδ T cell expansions from healthy adult donors and observe that highly potent natural killer lymphocytes expand with γδ T cells under zoledronate and IL-2 stimulation.
[Journal of Experimental Medicine] Scientists demonstrated that cutaneous vaccinia virus infection by scarification activates dermal lymphatic capillary junction tightening and lymph node lymphangiogenesis, which were associated with reduced fluid transport and cutaneous viral sequestration.
[Nature Genetics] The authors investigated the influence of human leukocyte antigen (HLA) alleles on TCR composition at the highly diverse complementarity determining region 3, which conferred antigen recognition.
[Communications Biology] Researchers reported the isolation of 3H4, a murine human leukocyte antigen E (HLA-E)-VL9-specific IgM antibody that enhanced killing of HLA-E-VL9-expressing cells by an NKG2A+ NK cell line.