lung cancer

[Nature Communications] By utilizing a ΔNp63-specific conditional knockout mouse model and xenograft models of lung adenocarcinoma and squamous cell carcinoma, scientists found that ∆Np63 promoted NSCLC by maintaining the lung stem cells necessary for lung cancer cell initiation and progression in quiescence.

[Lung Cancer Research Foundation] The Lung Cancer Research Foundation (LCRF) and KRAS Kickers announced a partnership aimed at raising much needed funds for research. Together they to pledge to fund at least one two-year grant in 2022 with the goal of improving outcomes for people with KRAS-mutant lung cancer.

[ACS Applied Materials & interfaces] Researchers developed a multimode nanoplatform to investigate tumor-initiating cancer stem cells, detected epigenetic changes, and subsequently explored their transformation signals following drug therapy.

[Cancer Discovery] Using metastatic models of EGFR-mutant lung cancer, the authors showed that cancer cells expressing high intracellular S100A9 escaped osimertinib and initiated brain relapses.

[Molecular Cancer therapeutics] Scientists selected five NSCLC patient-derived xenografts (PDXs) with genetic alterations from established PDXs and the corresponding molecular targeted therapy was administered orally for 21 consecutive days.

[Journal of Experimental & Clinical Cancer Research] The authors reported that stimuli from the embryonic lung could modulate the malignant phenotype of lung cancer cells, control their growth capacity and activate their differentiation into myofibroblasts.