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lymphocytes

Potent but Transient Immunosuppression of T Cells Is a General Feature of CD71+ Erythroid Cells

[Communications Biology] Researchers showed that in mice early-stage CD71+ erythroid cells expanded in anemia, had high levels of arginase 2 and reactive oxygen species.

Mustang Bio Announces Updated Interim Phase I/II Data for MB-106 in Patients with Relapsed or Refractory B Cell Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia

[Mustang Bio, Inc.] Mustang Bio, Inc. announced updated data from the ongoing Phase I/II clinical trial of MB-106, a CD20-targeted, autologous CAR T cell therapy for patients with relapsed or refractory B cell non-Hodgkin lymphomas and chronic lymphocytic leukemia.

Axicabtagene Ciloleucel as Second-Line Therapy for Large B-Cell Lymphoma

[New England Journal of Medicine] In a Phase III clinical trial, scientists randomly assigned, in a 1:1 ratio, patients with large B cell lymphoma that was refractory to or had relapsed no more than 12 months after first-line chemoimmunotherapy to receive axicabtagene ciloleucel or standard care.

SOX10 Requirement for Melanoma Tumor Growth Is Due, in Part, to Immune-Mediated Effects

[Cell Reports] Researchers investigated immune-related targets of SOX10 and observed positive regulation of herpesvirus entry mediator and carcinoembryonic-antigen cell-adhesion molecule 1.

Peripheral Immunophenotyping of AITD Subjects Reveals Alterations in Immune Cells in Pediatric vs Adult-Onset AITD

[iScience] Scientists performed phenotypic and functional characterization of peripheral blood immune cells from pediatric and adult-onset autoimmune thyroid disease (AITD) patients and age-matched controls using mass cytometry.

Effective CD4 T Cell Priming Requires Repertoire Scanning by CD301b+ Migratory cDC2 Cells upon Lymph Node Entry

[Science Immunology] Researchers showed that recently homed naïve polyclonal CD4 T cells were temporarily retained before leaving the lymph node.

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