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lymphocytes

Novel Combination of Bioactive Agents in Bilayered Dermal Patches Provides Superior Wound Healing

[Nanomedicine-Nanotechnology Biology and Medicine] Multifunctional bilayered dermal patches with antibacterial, antioxidant and anti-inflammatory properties were developed and compared for performance. Soluble eggshell membrane protein improved migration of human adult dermal fibroblasts, suggesting its contribution to wound healing.

CRISPR Therapeutics Announces FDA Regenerative Medicine Advanced Therapy (RMAT) Designation Granted to CTX110â„¢ for the Treatment of Relapsed or Refractory CD19+ B Cell Malignancies

[CRISPR Therapeutics] CRISPR Therapeutics announced that the FDA granted Regenerative Medicine Advanced Therapy designation to CTX110â„¢, its wholly-owned allogeneic CAR-T cell therapy targeting CD19+ B-cell malignancies.

Th17 Cell Master Transcription Factor RORC2 Regulates HIV-1 Gene Expression and Viral Outgrowth

[Proceedings of the National Academy of Sciences of the United States of America] The authors reported that RORC2 was a key host cofactor for HIV replication in Th17 cells. They found that specific inhibitors that bound to the RORC2 ligand-binding domain reduced HIV replication in CD4+ T cells.

Protective Mucosal Immunity against SARS-CoV-2 after Heterologous Systemic Prime-Mucosal Boost Immunization

[Nature Communications] Investigators reported that intranasal vaccinations with adenovirus 5 and 19a vectored vaccines following a systemic plasmid DNA or mRNA priming resulted in systemic and mucosal immunity in mice.

Simultaneous Silencing of A2aR and PD-1 as Immune Checkpoints by siRNA-Loaded Nanoparticles Enhances the Immunotherapeutic Potential of Dendritic Cell Vaccine in Tumor Experimental Models

[Life Sciences] Scientists inhibited two of the most important immune checkpoints expressed on T cells infiltrated in tumors, including PD-1 and A2aR. Ligation of PD-1 with PD-L1 and A2aR with adenosine significantly suppress T cell responses against tumor cells.

Sulforaphane Enhances the Antitumor Response of Chimeric Antigen Receptor T Cells by Regulating PD-1/PD-L1 Pathway

[BMC Medicine] The effect of combined SFN and CAR-T cells was determined in vitro using a co-culture system and in vivo using a xenograft mouse model. They furthered validated the effects of combination therapy in patients with cancer.

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