lymphocytes

[Nature Reviews Disease Primers] VEGF is a potent angiogenic factor that may have a role in the pathogenesis of the Kaposi sarcoma herpesvirus (KSHV)-negative idiopathic form of multicentric Castelman disease (MCD) and KSHV-MCD, as endothelial cell and blood vessel proliferation is an important component of MCD.

[Cytovia Therapeutics, Inc. (GlobeNewswire, Inc.)] Cytovia Therapeutics, Inc. and Cellectis announced that they have expanded their collaboration of TALEN® gene-edited iPSC-derived natural killer (NK) and chimeric antigen receptor (CAR)-NK cells to include new CAR target and development in China by Cytovia’s joint venture entity, CytoLynx Therapeutics.

[Journal of Clinical Investigation] Using barcoded pMHC multimers, scientists provided a comprehensive mapping of CD8+ T cells recognizing neoepitopes in Tumor-Infiltrating Lymphocyte infusion products and blood samples from 26 metastatic mela-noma patients who received adoptive cell therapy.

[Journal of Clinical Investigation] Using single-cell RNA sequencing and paired TCRα/β sequencing, researchers assessed the transcriptomes of CD154+ and CD137+ peanut-reactive T helper cells from 12 peanut-allergic patients longitudinally throughout oral immunotherapy.

[Trends in Cancer] Research on CD8+ T cell-dependent antitumor immunity has classically focused on its role in the primary tumor.

[Cancer Immunology Research] The authors showed that expression of the axon guidance molecule PlexinA4 in cytotoxic T cell, especially in effector/memory CD8+ T cells, was induced upon T cell activation, sustained in the circulation, but reduced when entering the tumor bed.