Neoantigen-Reactive CD8⁺ T Cells Affect Clinical Outcome of Adoptive Transfer with Tumor-Infiltrating Lymphocytes in Melanoma

Using barcoded pMHC multimers, scientists provided a comprehensive mapping of CD8+ T cells recognizing neoepitopes in Tumor-Infiltrating Lymphocyte infusion products and blood samples from 26 metastatic mela-noma patients who received adoptive cell therapy.