Researchers utilized T cells from mice that express LckS59A, which cannot accept a phosphate at residue 59, to initiate acute graft-versus-host disease.
[Journal of Clinical Investigation]
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The authors demonstrated that selective HDAC8 inhibition elicited effective and durable responses to immune-checkpoint blockade by co-opting adaptive immunity through enhancer reprogramming.
[Science Translational Medicine]
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Researchers presented data showing women presented less aggressive primary cutaneous squamous cell carcinoma and early strong immune activation.
[Clinical Cancer Research]
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Investigators revealed a role for myeloid-derived cells-derived hypochlorous acid (HOCl) as a small-molecule paracrine signaling factor that trans-inhibited inhibited IκB kinase (IKK) in melanoma tumor cells, mediating antitumor responses during early tumor progression.
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Scientists focus on immune dysfunction in newly diagnosed chronic myeloid leukemia patients, and the role that tyrosine kinase inhibitors and other therapies have in restoring immune surveillance.
Investigators showed that cyclin-dependent kinases 4 and 6 (CDK4/6i) could enhance efficacy of T cell-based therapies, such as adoptive T cell transfer or T cell-activating antibodies anti-OX40/anti-4-1BB, in murine breast cancer models.
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Uzhachenko, R. V., Bharti, V., Ouyang, Z., Blevins, A., Mont, S., Saleh, N., Lawrence, H. A., Shen, C., Chen, S.-C., Ayers, G. D., DeNardo, D. G., Arteaga, C., Richmond, A., & Vilgelm, A. E. (2021). Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors. Cell Reports, 35(1). https://doi.org/10.1016/j.celrep.2021.108944 Cite
Activation of cell mediated immunity produced a strong viral antigen specific CD8+ T lymphocyte response.
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Alwis, R. de, Gan, E. S., Chen, S., Leong, Y. S., Tan, H. C., Zhang, S. L., Yau, C., Low, J. G. H., Kalimuddin, S., Matsuda, D., Allen, E. C., Hartman, P., Park, J., Alayyoubi, M., Bhaskaran, H., Dukanovic, A., Bao, Y., Clemente, B., Vega, J., … Ooi, E. E. (2021). A Single Dose of Self-Transcribing and Replicating RNA Based SARS-CoV-2 Vaccine Produces Protective Adaptive Immunity In Mice. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.04.001 Cite
By using the Eµ-TCL1 adoptive transfer mouse model of chronic lymphocytic leukemia, scientists observed that ibrutinib effectively controled leukemia development, but also resulted in significantly lower numbers of CD8+ effector T-cells, with lower expression of activation markers, as well as impaired proliferation and effector function.
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Hanna, B. S., Yazdanparast, H., Demerdash, Y., Roessner, P. M., Schulz, R., Lichter, P., Stilgenbauer, S., & Seiffert, M. (2021). Combining ibrutinib and checkpoint blockade improves CD8+ T-cell function and control of chronic lymphocytic leukemia in Em-TCL1 mice. Haematologica, 106(4), 968–977. https://doi.org/10.3324/haematol.2019.238154 Cite
Scientists showed downregulation of mitochondria-derived genes and mitochondria-associated metabolic pathways in IFN-High patients from transcriptomic analysis of CD4+ and CD8+ T cells.
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Buang, N., Tapeng, L., Gray, V., Sardini, A., Whilding, C., Lightstone, L., Cairns, T. D., Pickering, M. C., Behmoaras, J., Ling, G. S., & Botto, M. (2021). Type I interferons affect the metabolic fitness of CD8 + T cells from patients with systemic lupus erythematosus. Nature Communications, 12(1), 1980. https://doi.org/10.1038/s41467-021-22312-y Cite
Scientists found that protective CD8+ T cells could be mobilized during viral infection even when TAP was absent in all hematopoietic cells.
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Barbet, G., Nair-Gupta, P., Schotsaert, M., Yeung, S. T., Moretti, J., Seyffer, F., Metreveli, G., Gardner, T., Choi, A., Tortorella, D., Tampé, R., Khanna, K. M., García-Sastre, A., & Blander, J. M. (2021). TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming. Nature Immunology, 1–13. https://doi.org/10.1038/s41590-021-00903-7 Cite
Researchers report an essential cross-talk between CAR T cell subsets and the TME for tumor control in an immunocompetent mouse B cell lymphoma model of anti-CD19 CAR T cell therapy.
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Boulch, M., Cazaux, M., Loe-Mie, Y., Thibaut, R., Corre, B., Lemaître, F., Grandjean, C. L., Garcia, Z., & Bousso, P. (2021). A cross-talk between CAR T cell subsets and the tumor microenvironment is essential for sustained cytotoxic activity. Science Immunology, 6(57). https://doi.org/10.1126/sciimmunol.abd4344 Cite