Multimodal Mapping of the Tumor and Peripheral Blood Immune Landscape in Human Pancreatic Cancer

Using a combination of CyTOF, single-cell RNA sequencing and multiplex immunohistochemistry on patient tumors, matched blood and non-malignant samples, scientists uncovered a complex network of immune-suppressive cellular interactions.
[Nature Cancer]
Steele, N. G., Carpenter, E. S., Kemp, S. B., Sirihorachai, V. R., The, S., Delrosario, L., Lazarus, J., Amir, E. D., Gunchick, V., Espinoza, C., Bell, S., Harris, L., Lima, F., Irizarry-Negron, V., Paglia, D., Macchia, J., Chu, A. K. Y., Schofield, H., Wamsteker, E.-J., … Pasca di Magliano, M. (2020). Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer. Nature Cancer, 1–16. https://doi.org/10.1038/s43018-020-00121-4 Cite
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Gene Expression Analysis in Formalin Fixed Paraffin Embedded Melanomas Is Associated with Density of Corresponding Immune Cells in Those Tissues

[Scientific Reports]
Gene expression analysis in formalin fixed paraffin embedded melanomas is associated with density of corresponding immune cells in those tissues | Scientific Reports. (n.d.). Retrieved October 27, 2020, from https://www.nature.com/articles/s41598-020-74996-9 Cite
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Early Emergence of T Central Memory Precursors Programs Clonal Dominance During Chronic Viral Infection

By mapping the long-term development of CD8+ T cell families derived from single naive precursors, scientists found that fate decisions made during the acute phase of murine cytomegalovirus infection could alter the level of memory inflation by more than 1,000-fold.
[Nature Immunology]
Grassmann, S., Mihatsch, L., Mir, J., Kazeroonian, A., Rahimi, R., Flommersfeld, S., Schober, K., Hensel, I., Leube, J., Pachmayr, L. O., Kretschmer, L., Zhang, Q., Jolly, A., Chaudhry, M. Z., Schiemann, M., Cicin-Sain, L., Höfer, T., Busch, D. H., Flossdorf, M., & Buchholz, V. R. (2020). Early emergence of T central memory precursors programs clonal dominance during chronic viral infection. Nature Immunology, 1–11. https://doi.org/10.1038/s41590-020-00807-y Cite
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Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation

Through an interaction-dependent labeling approach, intratumoral TSA-reactive CD4 +, CD8 + T cells, and TSA-suppressive CD4 + T cells could be detected and separated from bystander T cells based on their cell-surface enzymatic fucosyl-biotinylation.
[Cell]
Liu, Z., Li, J. P., Chen, M., Wu, M., Shi, Y., Li, W., Teijaro, J. R., & Wu, P. (2020). Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.09.048 Cite
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Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2, Most of which Are Not Located in the Spike Protein

Scientists used an unbiased, genome-wide screening technology to determine the precise peptide sequences in SARS-CoV-2 that are recognized by the memory CD8+ T cells of COVID-19 patients.
[Immunity]
Ferretti, A. P., Kula, T., Wang, Y., Nguyen, D. M. V., Weinheimer, A., Dunlap, G. S., Xu, Q., Nabilsi, N., Perullo, C. R., Cristofaro, A. W., Whitton, H. J., Virbasius, A., Olivier, K. J., Buckner, L. R., Alistar, A. T., Whitman, E. D., Bertino, S. A., Chattopadhyay, S., & MacBeath, G. (2020). Unbiased screens show CD8+ T cells of COVID-19 patients recognize shared epitopes in SARS-CoV-2, most of which are not located in the Spike protein. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.10.006 Cite
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TGF-β Suppresses Type 2 Immunity to Cancer

The authors showed that depletion of transforming growth factor-β receptor 2 (TGFβR2) in CD4+ T cells, but not CD8+ T cells, halts cancer progression as a result of tissue healing and remodeling of the blood vasculature, causing cancer cell hypoxia and death in distant avascular regions.
[Nature]
Liu, M., Kuo, F., Capistrano, K. J., Kang, D., Nixon, B. G., Shi, W., Chou, C., Do, M. H., Stamatiades, E. G., Gao, S., Li, S., Chen, Y., Hsieh, J. J., Hakimi, A. A., Taniuchi, I., Chan, T. A., & Li, M. O. (2020). TGF-β suppresses type 2 immunity to cancer. Nature, 1–6. https://doi.org/10.1038/s41586-020-2836-1 Cite
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The Differential Immune Responses to COVID-19 in Peripheral and Lung Revealed by Single-Cell RNA Sequencing

Using single-cell RNA sequencing, researchers characterized the peripheral blood mononuclear cells from uninfected controls and COVID-19 patients and cells in paired broncho-alveolar lavage fluid.
[Cell Discovery]
The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing | Cell Discovery. (n.d.). Retrieved October 20, 2020, from https://www.nature.com/articles/s41421-020-00225-2 Cite
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Naive CD8+ T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity

Using mass cytometry, scientists uncovered a naive CD8+ T cell population expressing CD95 that was enriched in patients with high compared with low cardiovascular disease.
[Arteriosclerosis Thrombosis and Vascular Biology]
Padgett Lindsey E., Dinh Huy Q., Wu Runpei, Gaddis Dalia E., Araujo Daniel J., Winkels Holger, Nguyen Anh, McNamara Coleen A., & Hedrick Catherine C. (n.d.). Naive CD8+ T Cells Expressing CD95 Increase Human Cardiovascular Disease Severity. Arteriosclerosis, Thrombosis, and Vascular Biology, 0(0), ATVBAHA.120.315106. https://doi.org/10.1161/ATVBAHA.120.315106 Cite
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Multiscale Fluorescent Tracking of Immune Cells in the Liver with a Highly Biocompatible Far-Red Emitting Polymer Probe

A newly-designed water-soluble far-red emitting polymer probe, 19K-6H, with a large Stokes shift, was thus evaluated for the tracking of primary immune CD8 T cells. 19K-6H-labelled primary CD8 T cells were injected to mice in a classical model of immune mediated hepatitis.
[Scientific Reports]
Multiscale fluorescent tracking of immune cells in the liver with a highly biocompatible far-red emitting polymer probe | Scientific Reports. (n.d.). Retrieved October 16, 2020, from https://www.nature.com/articles/s41598-020-74621-9 Cite
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Midkine Rewires the Melanoma Microenvironment Toward a Tolerogenic and Immune-Resistant State

Midkine was found to control the transcriptome of melanoma cells, allowing for coordinated activation of nuclear factor-κB and downregulation of interferon-associated pathways.
[Nature Medicine]
Cerezo-Wallis, D., Contreras-Alcalde, M., Troulé, K., Catena, X., Mucientes, C., Calvo, T. G., Cañón, E., Tejedo, C., Pennacchi, P. C., Hogan, S., Kölblinger, P., Tejero, H., Chen, A. X., Ibarz, N., Graña-Castro, O., Martinez, L., Muñoz, J., Ortiz-Romero, P., Rodriguez-Peralto, J. L., … Soengas, M. S. (2020). Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nature Medicine, 1–13. https://doi.org/10.1038/s41591-020-1073-3 Cite
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Stroma-Derived ANGPTL2 Establishes an Anti-Tumor Microenvironment during Intestinal Tumorigenesis

ANGPTL2 secreted from intestinal subepithelial myofibroblasts drove generation of Ly6Chigh immunostimulatory macrophages via NF-κB signaling to promote CD4+ Th1 cell responses that established an anti-tumor microenvironment during injury-induced intestinal tumorigenesis
[Oncogene]
Horiguchi, H., Kadomatsu, T., Miyata, K., Terada, K., Sato, M., Torigoe, D., Morinaga, J., Moroishi, T., & Oike, Y. (2020). Stroma-derived ANGPTL2 establishes an anti-tumor microenvironment during intestinal tumorigenesis. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01505-7 Cite
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