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Cancer Stem-Like Cells Evade CD8+CD103+ Tumor-Resident Memory T (TRM) Lymphocytes by Initiating an Epithelial-to-Mesenchymal Transition Program in a Human Lung Tumor Mode

[Journal For Immunotherapy of Cancer] Researchers supported the rational design of immunotherapeutic strategies targeting cancer stem cells to optimize their responsiveness to local CD8+CD103+ TRM cells for more efficient anticancer treatments.

Interferon-A Potentiates Anti-PD-1 Efficacy by Remodeling Glucose Metabolism in the Hepatocellular Carcinoma Microenvironment

[Cancer Discovery] Scientists found that a combination of interferon alpha and anti-PD-1-based immunotherapy resulted in enhanced antitumor activity in unresectable hepatocellular carcinoma patients.

Peripheral Blood CD4+CCR6+ Compartment Differentiates HIV-1 Infected or Seropositive Elite Controllers from Long-Term Successfully Treated Individuals

[Communications Biology] Scientists showed how people living with HIV-1 (PLWH) who naturally control the virus had a reduced proportion of CD4+CCR6+ and CD8+CCR6+ cells compared to PLWH on suppressive antiretroviral therapy and HIV-1 negative controls.

A Guide to Antigen Processing and Presentation

[Nature Reviews Immunology] Scientists describe the essentials of antigen processing and presentation and how the source proteins for these antigens are tagged for degradation, destroyed and ultimately displayed as peptides in complex with major histocompatibility complex molecules for T cell recognition.

Circadian Regulator CLOCK Drives Immunosuppression in Glioblastoma

[Cancer Immunology Research] Scientists showed that circadian locomotor output cycles kaput (CLOCK) and its heterodimeric partner brain and muscle ARNT-like 1 in glioma stem cells drive immunosuppression in glioblastoma.

LPA Suppresses T Cell Function by Altering the Cytoskeleton and Disrupting Immune Synapse Formation

[Proceedings of the National Academy of Sciences of the United States of America] The authors suggested that targeting lysophosphatidic acid (LPA) signaling in chronic inflammatory conditions may have rescued T cell function and promoted antiviral and antitumor immunity.