mRNA Vaccines Induce Durable Immune Memory to SARS-CoV-2 and Variants of Concern

The authors longitudinally profiled vaccine responses in SARS-CoV-2 naïve and recovered individuals for six months after vaccination.
[Science]
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Adoptive CD8+T-Cell Grafted with Liposomal Immunotherapy Drugs to Counteract the Immune Suppressive Tumor Microenvironment and Enhance Therapy for Melanoma

The immunosuppressive tumor microenvironment has become a formidable obstacle to the treatment of tumors using adoptive T cell therapy, in particular solid tumors. Effector OT-1 CD8+T cells conjugated with liposomal immune regulators were developed to address this issue.
[Nanoscale]
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CD73-Mediated Adenosine Production by CD8 T Cell-Derived Extracellular Vesicles Constitutes an Intrinsic Mechanism of Immune Suppression

The authors showed that extracellular vesicles isolated from the synovial fluid of patients with juvenile idiopathic arthritis contribute to T cell suppression in a CD73-dependent manner.
[Nature Communications]
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Proinflammatory Cytokines Promote TET2-Mediated DNA Demethylation during CD8 T Cell Effector Differentiation

To gain insight into the signaling determinants of effector-associated DNA methylation programming among CD8 T cells, scientists explore the role of interleukin (IL)-12 in the imprinting of IFNg expression during CD8 T cell priming.
[Cell Reports]
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PI3Kδ Coordinates Transcriptional, Chromatin, and Metabolic Changes to Promote Effector CD8+ T Cells at the Expense of Central Memory

Using patient samples and a mouse model, scientists demonstrated that, upon activation, Pik3cdE1020K/+ CD8+ T cells exhibited exaggerated features of effector populations both in vitro and after viral infection that were associated with increased Fas-mediated apoptosis.
[Cell Reports]
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Activation of Toll-Like Receptor 2 Enhances Peripheral and Tumor-Infiltrating CD8+ T Cell Cytotoxicity in Patients with Gastric Cancer

Scientists investigated the regulation of TLR activation to CD8+ T cells has not been fully elucidated in gastric cancer.
[BMC Immunology]
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Leukemic Progenitor Cells Enable Immunosuppression and Post-Chemotherapy Relapse via IL-36–Inflammatory Monocyte Axis

Researchers showed that abnormal IL-36 production activated by NF-κB was an essential feature of mouse and human leukemic progenitor cells.
[Science Advances]
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Phase II Evaluation of Stereotactic Ablative Radiotherapy (SABR) and Immunity in 11C-Choline-PET/CT-Identified Oligometastatic Castration-Resistant Prostate Cancer

Stereotactic ablative radiotherapy induces anti-tumor immunity in clinical and preclinical studies, but immunological biomarkers are lacking.
[Clinical Cancer Research]
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The Legacy of Maternal SARS-CoV-2 Infection on the Immunology of the Neonate

Scientists characterized the immunology of neonates born to mothers with confirmed SARS-CoV-2 infection during pregnancy. They showed that maternal SARS-CoV-2 infection affected the neonatal immune system.
[Nature Immunology]
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Niraparib Exhibits a Synergistic Anti-Tumor Effect with PD-L1 Blockade by Inducing an Immune Response in Ovarian Cancer

Programmed death ligand 1 (PD-L1) expression in human ovarian cancer cells after PARP inhibitors treatment was examined by western blotting and flow cytometry.
[Journal of Translational Medicine]
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Characterization of Humoral and SARS-CoV-2 Specific T Cell Responses in People Living with HIV

The authors showed that the majority of people living with HIV with ART suppressed HIV viral load, mounted a detectable adaptive immune response to SARS-CoV-2.
[Nature Communications]
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