[Journal For Immunotherapy of Cancer] Researchers supported the rational design of immunotherapeutic strategies targeting cancer stem cells to optimize their responsiveness to local CD8+CD103+ TRM cells for more efficient anticancer treatments.
[Communications Biology] Scientists showed how people living with HIV-1 (PLWH) who naturally control the virus had a reduced proportion of CD4+CCR6+ and CD8+CCR6+ cells compared to PLWH on suppressive antiretroviral therapy and HIV-1 negative controls.
[Nature Reviews Immunology] Scientists describe the essentials of antigen processing and presentation and how the source proteins for these antigens are tagged for degradation, destroyed and ultimately displayed as peptides in complex with major histocompatibility complex molecules for T cell recognition.
[Cancer Immunology Research] Scientists showed that circadian locomotor output cycles kaput (CLOCK) and its heterodimeric partner brain and muscle ARNT-like 1 in glioma stem cells drive immunosuppression in glioblastoma.
[Proceedings of the National Academy of Sciences of the United States of America] The authors suggested that targeting lysophosphatidic acid (LPA) signaling in chronic inflammatory conditions may have rescued T cell function and promoted antiviral and antitumor immunity.