lymphocytes

[Science Immunology] Researchers investigated the human antibody repertoire, avidity maturation, epitope specificity, and function after immunization with a single dose of Vi-tetanus toxoid conjugate vaccine and after a booster with plain Vi polysaccharide.

[Cell Reports] In three murine models, CD8+ cells bearing resident memory T cells markers remained in previously inflamed joints during remission.

[Science Immunology] Researchers used an orthotopic non–small cell lung cancer mouse model to study immune checkpoint blockade-refractory CD8+ T cell responses.

[Phytotherapy Research] Researchers explored the apoptotic mechanism of Moracin D in prostate cancer cells in association with peroxisome proliferator-activated receptor gamma (PPAR-γ)-related signaling involved in lipid metabolism.

[Cell Death & Disease] The authors found that apoptosis-associated epitopes-specific CD8+ T cells were present in the lymphoid organs of unprimed mice, proliferated under peptide stimulation in vitro, but failed to respond to peptide immunization in vivo, suggesting a physiological control of this response.

[Journal of Clinical Investigation] The authors highlight the current understanding, evolving concepts, and unanswered questions provided by this unique opportunity to determine mechanisms by which a viral infection can be exacerbated by, and even trigger, autoimmunity.