lymphocytes

[Cell Reports] To gain insight into the signaling determinants of effector-associated DNA methylation programming among CD8 T cells, scientists explored the role of interleukin-12 in the imprinting of IFNg expression during CD8 T cell priming.

[Cell Reports] Using patient samples and a mouse model, scientists demonstrated that, upon activation, Pik3cdE1020K/+ CD8+ T cells exhibited exaggerated features of effector populations both in vitro and after viral infection that were associated with increased Fas-mediated apoptosis.

[Immunity] Researchers examined how the cholesterol metabolite 25-hydroxycholesterol impacted the intestinal B cell response. Mice lacking cholesterol 25-hydroxylase, the enzyme generating 25-HC, had higher frequencies of immunoglobulin A-secreting antigen-specific B cells upon immunization or infection.

[Science Advances] Researchers showed that abnormal IL-36 production activated by NF-κB was an essential feature of mouse and human leukemic progenitor cells.

[Gates Biomanufacturing Facility] The Gates Biomanufacturing Facility signed a continued strategic agreement with Nkarta to manufacture clinical supply of therapeutic Natural Killer cells. As part of this collaboration, GBF will continue to manufacture NKX101, an immunotherapy currently in a Phase I clinical trial for patients with relapsed/refractory acute myeloid leukemia or higher-risk myelodysplastic syndromes.

[Sutro Biopharma, Inc.] Sutro Biopharma, Inc and BioNova Pharmaceuticals Limited announced an option agreement for BioNova to develop and commercialize STRO-001, a CD74-targeting Antibody-Drug Conjugate, for patients with hematologic cancers, in Greater China, including mainland China, Hong Kong, Macau and Taiwan.