lymphocytes

[Cell Reports] Scientists demonstrated that a characteristic additional third nuclear factor κB binding site in the long terminal repeat promoter allows subtype C HIV-1 strains to evade restriction by nuclear PYHIN proteins.

[Experimental and Molecular Medicine] Researchers defined a new signaling pathway that regulated the transcription and expression of PD-L1 upon TGF-β treatment, which might have a significant impact on research into the application of immunotherapy in treating lung cancer.

[Celularity, Inc.] Celularity Inc. and Oncternal Therapeutics, Inc. announced they have entered into a research collaboration to evaluate placental derived-cellular therapies targeting receptor-tyrosine kinase-like Orphan Receptor 1.

[Journal of Hematology & Oncology] The synergistic effect between Bivalent manganese and YM101 in vitro was determined by one-way mixed lymphocyte reaction, CFSE dilution assay, and cytokine detection.

[Cell Reports Methods] The authors evaluated the presentation of mutant KRAS peptides on individual HLA-I molecules using targeted mass spectrometry and identify 13 unpublished KRASG12C/D/R/V mutation/HLA-I pairs and nine previously described pairs.

[Journal of Molecular and Cellular Cardiology] Investigators performed single-cell profiling of 35,245 cells from two venous malformation samples and three cavernous venous malformation samples, with a focus on endothelial cells, smooth muscle cells and immune microenvironment.