lymphocytes

[Journal of Immunology] The authors summarize the latest research on the epigenetic regulation of CTL differentiation as well as provide a combined model that contemplates them.

[Adaptimmune Therapeutics plc] Adaptimmune Therapeutics plc announced that it has entered into a strategic collaboration and license agreement with Genentech to develop and commercialize allogeneic cell therapies to treat multiple oncology indications. Adaptimmune will be responsible for developing clinical candidates using its iPSC derived allogeneic platform to produce T-cells.

[Immunity] To address mechanisms of durable and aborted control of viremia, researchers evaluated immunologic and virologic parameters longitudinally among 34 HIV-infected subjects with differential outcomes.

[Journal of Clinical Investigation] Scientists tested the sensitivity and performance of a simple and rapid SARS-CoV-2 spike protein–specific T cell test based on the stimulation of whole blood with peptides covering the SARS-CoV-2 spike protein, followed by cytokine measurement in different cohorts.

[Nature Reviews Immunology] Scientists review the emerging evidence that supports the existence of such a population of circulating resident memory T cell progenitors, discuss current insights into their formation and highlight open questions in the field.

[Science Translational Medicine] Scientists performed single-cell RNA sequencing on affected and unaffected skin from patients with vitiligo, as well as healthy controls, to define the role of each cell type in coordinating autoimmunity during disease progression.