lymphocytes

[iScience] Scientists reported the development of an intranasal subunit vaccine that uses lyophilized spike protein and liposomal STING agonist as an adjuvant.

[Cellular & Molecular Immunology] The authors review the works that have elucidated the function of SARS-CoV-2-specific T cells in patients and in vaccinated individuals.

[Blood Advances] Researchers conducted a Phase II study to test the activity of bortezomib and rituximab in combination with a pediatric-inspired regimen during induction therapy in newly diagnosed adolescents and adults with CD20-positive, Philadelphia (Ph)-negative precursor B-cell acute lymphoblastic leukemia.

[Leukemia] The average survival time was shorter in patients with JAK/STAT and PHF6 comutation than that in other patients, suggesting a potential role of PHF6 in leukemia progression.

[Immunity] By sensing IL-2 and cross-presenting hepatocellular antigens, a subset of kupffer cells overcame the tolerogenic potential of the hepatic microenvironment, suggesting new strategies for boosting hepatic T cell immunity.

[Cell Reports] Scientists reported the development of an improved system for monitoring HIV-1 fate at single-cell and population levels and showed the diverse applications of this system to study specific aspects of HIV-1 fate in different cell types and under different environments.