lymphocytes

[Nature Reviews Clinical Oncology] Scientists provide an overview of T cell costimulation by CD28 and 4-1BB and, using the available preclinical and clinical data, compare the efficacy and toxicity profiles associated with CARs containing either costimulatory domain.

[Nature Reviews Genetics] Ex vivo and in vivo cell-based biosensors and therapeutics have been developed to target a wide range of diseases including cancer, microbiome dysbiosis and autoimmune and metabolic diseases.

[Cancer Immunology, Immunotherapy] To determine the immune-modulatory influence of CSC in small cell lung cancer (SCLC), scientists focused on the characterization of CD44+CD90+ CSC-like subpopulations in SCLC.

[Scientific Reports] In MC38 tumors, only endothelial cells (ECs) strongly express APJ, a cognate receptor for Apelin, indicating that EC-derived Apelin might regulate tumor formation in an autocrine manner.

[Cancer Discovery] MDM2 inhibitor ALRN-6924 induced a viral mimicry pathway and tumor inflammation signature genes in melanoma patients.

[Clinical Cancer Research] The authors review the known functions of B-cells in the tumor microenvironment, the contribution of B-cells to the anti-tumor activity of immunotherapies, and the role of B-cells in the overall survival of cancer patients.