In mild COVID-19, CD8+ resident-memory and CD4+ T-helper-17 cells underwent active expansion towards the end of the trajectory, and were characterized by good effector functions, while in critical COVID-19 they remain more naïve.
[Cell Research]
Wauters, E., Van Mol, P., Garg, A. D., Jansen, S., Van Herck, Y., Vanderbeke, L., Bassez, A., Boeckx, B., Malengier-Devlies, B., Timmerman, A., Van Brussel, T., Van Buyten, T., Schepers, R., Heylen, E., Dauwe, D., Dooms, C., Gunst, J., Hermans, G., Meersseman, P., … Lambrechts, D. (2021). Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages. Cell Research, 1–19. https://doi.org/10.1038/s41422-020-00455-9 Cite
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