Selective and Cross-Reactive SARS-CoV-2 T Cell Epitopes in Unexposed Humans

Using human blood samples derived before the SARS-CoV-2 virus was discovered in 2019, the authors mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilitate precise interrogation of the SARS-CoV-2-specific CD4+ T cell repertoire.
[Science]
Mateus, J., Grifoni, A., Tarke, A., Sidney, J., Ramirez, S. I., Dan, J. M., Burger, Z. C., Rawlings, S. A., Smith, D. M., Phillips, E., Mallal, S., Lammers, M., Rubiro, P., Quiambao, L., Sutherland, A., Yu, E. D., Antunes, R. da S., Greenbaum, J., Frazier, A., … Weiskopf, D. (2020). Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans. Science. https://doi.org/10.1126/science.abd3871 Cite
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CD8+ T Cells Are Crucial for Humoral Immunity Establishment by SA14-14-2 Live Attenuated Japanese Encephalitis Vaccine in Mice

In lethal virus challenge, investigators showed that CD4+ T‐cells alone, but not CD8+ T‐cells, were sufficient to confer vaccine‐mediated protection.
[European Journal of Immunology]
Kalia, A., Agrawal, M., & Gupta, N. (n.d.). CD8+ T cells are crucial for humoral immunity establishment by SA14-14-2 live attenuated Japanese encephalitis vaccine in mice. European Journal of Immunology, n/a(n/a). https://doi.org/10.1002/eji.202048745 Cite
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Marginal Zone Formation Requires ACKR3 Expression on B Cells

The authors showed that expression of atypical chemokine receptor 3 defined two equal-sized populations of mouse marginal B cells
[Cell Reports]
Radice, E., Ameti, R., Melgrati, S., Foglierini, M., Antonello, P., Stahl, R. A. K., Thelen, S., Jarrossay, D., & Thelen, M. (2020). Marginal Zone Formation Requires ACKR3 Expression on B Cells. Cell Reports, 32(5). https://doi.org/10.1016/j.celrep.2020.107951 Cite
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Mucosal or Systemic Microbiota Exposures Shape the B Cell Repertoire

Microbial exposures at the intestinal mucosa generated oligoclonal responses that differed from those of germ-free mice, and from the diverse repertoire that was generated after intravenous systemic exposure to microbiota.
[Nature]
Li, H., Limenitakis, J. P., Greiff, V., Yilmaz, B., Schären, O., Urbaniak, C., Zünd, M., Lawson, M. A. E., Young, I. D., Rupp, S., Heikenwälder, M., McCoy, K. D., Hapfelmeier, S., Ganal-Vonarburg, S. C., & Macpherson, A. J. (2020). Mucosal or systemic microbiota exposures shape the B cell repertoire. Nature, 1–5. https://doi.org/10.1038/s41586-020-2564-6 Cite
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Infection during the First Year in Patients Treated with CD19 CAR T Cells for Diffuse Large B Cell Lymphoma

The authors analyzed 60 patients with diffuse large B cell lymphoma treated with FDA-approved CD19 chimeric antigen receptor (CAR) T cells and report the incidence, risk factors, and management of infections during the first year after treatment.
[Blood Cancer Journal]
Wudhikarn, K., Palomba, M. L., Pennisi, M., Garcia-Recio, M., Flynn, J. R., Devlin, S. M., Afuye, A., Silverberg, M. L., Maloy, M. A., Shah, G. L., Scordo, M., Dahi, P. B., Sauter, C. S., Batlevi, C. L., Santomasso, B. D., Mead, E., Seo, S. K., & Perales, M.-A. (2020). Infection during the first year in patients treated with CD19 CAR T cells for diffuse large B cell lymphoma. Blood Cancer Journal, 10(8), 1–11. https://doi.org/10.1038/s41408-020-00346-7 Cite
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Treatment of Mice with S4B6 IL-2 Complex Prevents Lethal Toxoplasmosis via IL-12- and IL-18-Dependent Interferon-Gamma Production by Non-CD4 Immune Cells

Scientists investigated the in vivo regulation of IFN-γ production by CD8+ T cells, DN T cells and NK cells in response to acute Toxoplasma gondii infection.
[Scientific Reports]
Kupz, A., Pai, S., Giacomin, P. R., Whan, J. A., Walker, R. A., Hammoudi, P.-M., Smith, N. C., & Miller, C. M. (2020). Treatment of mice with S4B6 IL-2 complex prevents lethal toxoplasmosis via IL-12- and IL-18-dependent interferon-gamma production by non-CD4 immune cells. Scientific Reports, 10(1), 13115. https://doi.org/10.1038/s41598-020-70102-1 Cite
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In Situ Neutrophil Efferocytosis Shapes T Cell Immunity to Influenza Infection

Newly infiltrated inflammatory monocytes became a chief pool of phagocytes and played a key role in the clearance of highly motile apoptotic neutrophils during the resolution phase.
[Nature Immunology]
Lim, K., Kim, T., Trzeciak, A., Amitrano, A. M., Reilly, E. C., Prizant, H., Fowell, D. J., Topham, D. J., & Kim, M. (2020). In situ neutrophil efferocytosis shapes T cell immunity to influenza infection. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0746-x Cite
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Impact of Vaccine Type on HIV-1 Vaccine Elicited Antibody Durability and B Cell Gene Signature

To assess the impact of vaccine type on antibody responses, investigators measured IgG isotypes against four consensus HIV antigens from two weeks to ten years post HIV-1 vaccination and used mixed effects models to estimate half-life of responses in four human clinical trials.
[Scientific Reports]
Palli, R., Seaton, K. E., Piepenbrink, M. S., Hural, J., Goepfert, P. A., Laher, F., Buchbinder, S. P., Churchyard, G., Gray, G. E., Robinson, H. L., Huang, Y., Janes, H., Kobie, J. J., Keefer, M. C., Tomaras, G. D., & Thakar, J. (2020). Impact of vaccine type on HIV-1 vaccine elicited antibody durability and B cell gene signature. Scientific Reports, 10(1), 13031. https://doi.org/10.1038/s41598-020-69007-w Cite
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Follicular Helper T Cell Profiles Predict Response to Costimulation Blockade in Type 1 Diabetes

Unbiased bioinformatics analysis identified that inducible costimulatory molecule (ICOS)+ folliular helper T cells and other ICOS+ populations, including peripheral helper T cells, were highly sensitive to costimulation blockade.
[Nature Immunology]
Edner, N. M., Heuts, F., Thomas, N., Wang, C. J., Petersone, L., Kenefeck, R., Kogimtzis, A., Ovcinnikovs, V., Ross, E. M., Ntavli, E., Elfaki, Y., Eichmann, M., Baptista, R., Ambery, P., Jermutus, L., Peakman, M., Rosenthal, M., & Walker, L. S. K. (2020). Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0744-z Cite
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Single-Cell Atlas of Colonic CD8+ T Cells in Ulcerative Colitis

Scientists compiled an unbiased atlas of human colonic CD8+ T cells in health and ulcerative colitis using single-cell transcriptomics with T-cell receptor repertoire analysis and mass cytometry.
[Nature Medicine]
Corridoni, D., Antanaviciute, A., Gupta, T., Fawkner-Corbett, D., Aulicino, A., Jagielowicz, M., Parikh, K., Repapi, E., Taylor, S., Ishikawa, D., Hatano, R., Yamada, T., Xin, W., Slawinski, H., Bowden, R., Napolitani, G., Brain, O., Morimoto, C., Koohy, H., & Simmons, A. (2020). Single-cell atlas of colonic CD8 + T cells in ulcerative colitis. Nature Medicine, 1–11. https://doi.org/10.1038/s41591-020-1003-4 Cite
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LW-213 Induces Cell Apoptosis in Human Cutaneous T-cell Lymphomas by Activating PERK–eIF2α–ATF4–CHOP Axis

Researchers showed that LW-213 dose-dependently inhibited human cutaneous T-cell lymphoma cell lines with IC50 values of around 10 μM, meanwhile it potently inhibited primary leukemia cells derived from peripheral blood of T-cell lymphoma patients.
[Acta Pharmacologica Sinica]
Yu, X., Zhu, M., Wang, J., Li, H., Hu, P., Qing, Y., Wang, X., Wang, H., Wang, Z., Xu, J., Guo, Q., & Hui, H. (2020). LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK–eIF2α–ATF4–CHOP axis. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-020-0466-7 Cite
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FDA Approves Monjuvi® (Tafasitamab-cxix) in Combination with Lenalidomide for the Treatment of Adult Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

MorphoSys AG and Incyte announced that the FDA has approved Monjuvi in combination with lenalidomide for the treatment of adult patients with relapsed or refractory DLBCL not otherwise specified, including DLBCL arising from low grade lymphoma, and who are not eligible for autologous stem cell transplant.
[MorphoSys AG]
Press Release

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