Myeloid Cell–Derived HOCl Is a Paracrine Effector That Trans-inhibits IKK/NF-κB in Melanoma Cells and Limits Early Tumor Progression

Investigators revealed a role for myeloid-derived cells-derived hypochlorous acid (HOCl) as a small-molecule paracrine signaling factor that trans-inhibited inhibited IκB kinase (IKK) in melanoma tumor cells, mediating antitumor responses during early tumor progression.
[Science Signaling]
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The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy?

The authors disscuss evidence on the ability of perinatal cells to inhibit B cell proliferation, impair B cell differentiation, and promote regulatory B cell formation.
[International Journal of Molecular Sciences]
Magatti, M., Masserdotti, A., Cargnoni, A., Papait, A., Stefani, F. R., Silini, A. R., & Parolini, O. (2021). The Role of B Cells in PE Pathophysiology: A Potential Target for Perinatal Cell-Based Therapy? International Journal of Molecular Sciences, 22(7), 3405. https://doi.org/10.3390/ijms22073405 Cite
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City of Hope Enters Licensing Agreements with CytoImmune Therapeutics Inc. to Develop Portfolio of Chimeric Antigen Receptor-Natural Killer Therapies

City of Hope and CytoImmune Therapeutics Inc. have entered into worldwide exclusive license agreements to several patent applications related to methods to generate large numbers of fully functional natural killer (NK) cells derived from umbilical cord blood and compositions of chimeric receptors (CAR) for targeting NK cells to tumors.
[CytoImmune Therapeutics, Inc. (BusinessWire, Inc)]
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Cell-Programmed Nutrient Partitioning in the Tumor Microenvironment

Researchers used PET tracers to measure the access to and uptake of glucose and glutamine by specific cell subsets in the tumor microenvironment. Notably, myeloid cells had the greatest capacity to take up intratumoral glucose, followed by T cells and cancer cells, across a range of cancer models.
[Nature]
Reinfeld, B. I., Madden, M. Z., Wolf, M. M., Chytil, A., Bader, J. E., Patterson, A. R., Sugiura, A., Cohen, A. S., Ali, A., Do, B. T., Muir, A., Lewis, C. A., Hongo, R. A., Young, K. L., Brown, R. E., Todd, V. M., Huffstater, T., Abraham, A., O’Neil, R. T., … Rathmell, W. K. (2021). Cell-programmed nutrient partitioning in the tumour microenvironment. Nature, 1–7. https://doi.org/10.1038/s41586-021-03442-1 Cite
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Single-Cell Analysis of FOXP3 Deficiencies in Humans and Mice Unmasks Intrinsic and Extrinsic CD4+ T Cell Perturbations

CD4+ T cells in patients with IPEX syndrome and Foxp3-deficient mice were analyzed by single-cell cytometry and RNA-sequencing, revealing heterogeneous Treg-like cells, some very similar to normal Treg cells, others more distant.
[Nature Immunology]
Zemmour, D., Charbonnier, L.-M., Leon, J., Six, E., Keles, S., Delville, M., Benamar, M., Baris, S., Zuber, J., Chen, K., Neven, B., Garcia-Lloret, M. I., Ruemmele, F. M., Brugnara, C., Cerf-Bensussan, N., Rieux-Laucat, F., Cavazzana, M., André, I., Chatila, T. A., … Benoist, C. (2021). Single-cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4 + T cell perturbations. Nature Immunology, 1–13. https://doi.org/10.1038/s41590-021-00910-8 Cite
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Temporal Multiomic Modeling Reveals a B-Cell Receptor Proliferative Program in Chronic Lymphocytic Leukemia

Using an original ex vivo model of B-cell receptor-induced proliferation of chronic lymphocytic leukemia cells, researchers generated 108 temporal transcriptional and proteomic profiles from one hour up to four days after BCR activation.
[Leukemia]
Schleiss, C., Carapito, R., Fornecker, L.-M., Muller, L., Paul, N., Tahar, O., Pichot, A., Tavian, M., Nicolae, A., Miguet, L., Mauvieux, L., Herbrecht, R., Cianferani, S., Freund, J.-N., Carapito, C., Maumy-Bertrand, M., Bahram, S., Bertrand, F., & Vallat, L. (2021). Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia. Leukemia, 1–12. https://doi.org/10.1038/s41375-021-01221-5 Cite
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Improving Outcomes in Chronic Myeloid Leukemia through Harnessing the Immunological Landscape

Scientists focus on immune dysfunction in newly diagnosed chronic myeloid leukemia patients, and the role that tyrosine kinase inhibitors and other therapies have in restoring immune surveillance.
[Leukemia]
Hsieh, Y.-C., Kirschner, K., & Copland, M. (2021). Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape. Leukemia, 1–14. https://doi.org/10.1038/s41375-021-01238-w Cite
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CAR Directs T Cell Adaptation to Bile Acids in the Small Intestine

Scientists identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells that could safeguard against bile acid toxicity and inflammation in the mouse small intestine.
[Nature]
Chen, M. L., Huang, X., Wang, H., Hegner, C., Liu, Y., Shang, J., Eliason, A., Diao, H., Park, H., Frey, B., Wang, G., Mosure, S. A., Solt, L. A., Kojetin, D. J., Rodriguez-Palacios, A., Schady, D. A., Weaver, C. T., Pipkin, M. E., Moore, D. D., & Sundrud, M. S. (2021). CAR directs T cell adaptation to bile acids in the small intestine. Nature, 1–5. https://doi.org/10.1038/s41586-021-03421-6 Cite
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Prognostic and Therapeutic Implications of Extracellular Matrix Associated Gene Signature in Renal Clear Cell Carcinoma

The expression of ECM-related genes was explored for prognostic and immunological implication in clear cell renal clear cell carcinoma.
[Scientific Reports]
Ahluwalia, P., Ahluwalia, M., Mondal, A. K., Sahajpal, N., Kota, V., Rojiani, M. V., Rojiani, A. M., & Kolhe, R. (2021). Prognostic and therapeutic implications of extracellular matrix associated gene signature in renal clear cell carcinoma. Scientific Reports, 11(1), 7561. https://doi.org/10.1038/s41598-021-86888-7 Cite
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Metabolic Modulation by CDK4/6 Inhibitor Promotes Chemokine-Mediated Recruitment of T Cells Into Mammary Tumors

Investigators showed that cyclin-dependent kinases 4 and 6 (CDK4/6i) could enhance efficacy of T cell-based therapies, such as adoptive T cell transfer or T cell-activating antibodies anti-OX40/anti-4-1BB, in murine breast cancer models.
[Cell Reports]
Uzhachenko, R. V., Bharti, V., Ouyang, Z., Blevins, A., Mont, S., Saleh, N., Lawrence, H. A., Shen, C., Chen, S.-C., Ayers, G. D., DeNardo, D. G., Arteaga, C., Richmond, A., & Vilgelm, A. E. (2021). Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors. Cell Reports, 35(1). https://doi.org/10.1016/j.celrep.2021.108944 Cite
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How to Turn Up the Heat on the Cold Immune Microenvironment of Metastatic Prostate Cancer

The authors discuss the immunopathology of the prostate tumor microenvironment, strategies for treating prostate cancer with immunotherapies, and a perspective on potential approaches to enhancing the efficacy of immunotherapies.
[Prostate Cancer and Prostatic Diseases]
Stultz, J., & Fong, L. (2021). How to turn up the heat on the cold immune microenvironment of metastatic prostate cancer. Prostate Cancer and Prostatic Diseases, 1–21. https://doi.org/10.1038/s41391-021-00340-5 Cite
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