lymphocytes

[Nature] Scientists demonstrated that a trispecific antibody to HER2, CD3 and CD28 stimulated regression of breast cancers in a humanized mouse model through a mechanism involving CD4-dependent inhibition of tumor cell cycle progression.

[Mucosal Immunology] Investigators hypothesize that memory responses to antigens from the microbiota must be ‘licensed’ by inflammatory signals activated by invasion of the host by microorganisms.

[PLoS Biology] Scientists reported that mice with Treg cell–specific ablation of miR-142 developed a fatal systemic autoimmune disorder due to a breakdown in peripheral T cell tolerance.

[Advanced Healthcare Materials] Investigators developed a delivery platform for small extracellular vesicles derived from gingival MSCs to treat periodontitis.

[Nature Biomedical Engineering] Researchers reported the design, synthesis and performance of a bismuth-based nanoscale metal-organic framework that modulated the immunological and mechanical properties of the tumor microenvironment for enhanced radiotherapy-radiodynamic therapy.

[Leukemia] Secondary transplantation from PDX and ΔPTEN models of T-cell acute lymphoblastic leukemia (T-ALL), confirmed delayed leukemia development and extended survival of mice engrafted with T-ALL from ARV-825 treated mice, providing functional confirmation of depletion of leukemia-initiating cells.