lymphocytes

[Journal of Clinical Investigation] Investigators reported that SUMO-specific protease 7 sensed oxidative stress to maintain the CD8+ T cell metabolic state and antitumor functions.

[Science] Scientists longitudinally profiled SARS-CoV-2 spike-specific serological and memory B cell responses in individuals receiving either homologous or heterologous prime-boost vaccination.

[Cell Host & Microbe] Investigators reported the development of two pools of experimentally-defined SARS-CoV-2 T cell epitopes, that in combination with spike, were used to discriminate four groups of subjects with different SARS-CoV-2 infection and COVID-19 vaccine status.

[Trends in Molecular Medicine] Scientists characterized NK cells in healthy individuals and immunocompromised patients in the course of an anti-SARS-CoV-2 BNT162b2 mRNA prospective, open-label clinical vaccine trial.

[Immunological Reviews] Scientists review our current understanding of how each of the three signals plays a role in three different autoimmune diseases and highlight the genetic polymorphisms that predispose individuals to autoimmunity.

[Leukemia] In co-cultures from 28 different chronic lymphocytic leukemia patients, the authors detected an expansion of T-follicular helper cells based on PD-1, BCL6, and ICOS expression, with increased IL-21 and downmodulated CD40L surface expression.