Investigators characterized a population of interleukin 17-producing γδ T cells that seeded the testis of naive C57BL/6 mice, expand at puberty and persisted throughout adulthood.
6445212 S6A8FMZ3 items 1 apa default asc 1
Wilharm, A., Brigas, H. C., Sandrock, I., Ribeiro, M., Amado, T., Reinhardt, A., Demera, A., Hoenicke, L., Strowig, T., Carvalho, T., Prinz, I., & Ribot, J. C. (2020). Microbiota-dependent expansion of testicular IL-17-producing Vγ6 + γδ T cells upon puberty promotes local tissue immune surveillance. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-020-0330-6 Cite
Investigators demonstrated that LRCH1 directly bound linker for activation of T cells (LAT), reduced LAT phosphorylation and interaction with GRB2, and also promoted the endocytosis of LAT.
[Proceedings of the National Academy of Sciences of the United States of America]
6445212 YDPZM8EQ items 1 apa default asc 1
Liu, C., Xu, X., Han, L., Wan, X., Zheng, L., Li, C., Liao, Z., Xiao, J., Zhong, R., Zheng, X., Wang, Q., Li, Z., Chen, H., Wei, B., & Wang, H. (2020). LRCH1 deficiency enhances LAT signalosome formation and CD8+ T cell responses against tumors and pathogens. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2000970117 Cite
Scientists found that incorporation of the CD3ε cytoplasmic domain into a second-generation chimeric antigen receptor (CAR) improved antitumor activity of CAR-T cells.
1254621 TSX85YMF items 1 apa default asc 1
Exosomes were isolated from control and IFN-γ-primed mesenchymal stem cells and were verified by transmission electron microscope and immunofluorescence staining.
[Cell Death & Disease]
1254621 R6GHK246 items 1 apa default asc 1
Scientists describe the characteristics of natural killer (NK) cells from multiple cell sources, including PSCs, the chimeric antigen receptor (CAR)-modification method and strategy for these NK cells.
[International Journal of Hematology]
Researchers report that IL-7Rα downregulation was necessary to maximize IL-2R signaling. While IL-7Rα overexpression promoted IL-7 signaling, unexpectedly, IL-2 signaling was suppressed in the same cells.
6445212 KAVJTCYZ items 1 apa default asc 1
Waickman, A. T., Keller, H. R., Kim, T.-H., Luckey, M. A., Tai, X., Hong, C., Molina-Paris, C., Walsh, S. T. R., & Park, J.-H. (2020). The cytokine receptor IL-7Rα impairs IL-2 receptor signaling and constrains the in vitro differentiation of Foxp3+ Treg cells. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101421 Cite
Scientists found that PTPN2 deficiency renders cells in vivo and in vitro less dependent on survival-promoting cytokines, such as interleukin (IL)-2 and IL-15.
6445212 Q3QD3DZY items 1 apa default asc 1
Flosbach, M., Oberle, S. G., Scherer, S., Zecha, J., Hoesslin, M. von, Wiede, F., Chennupati, V., Cullen, J. G., List, M., Pauling, J. K., Baumbach, J., Kuster, B., Tiganis, T., & Zehn, D. (2020). PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells. Cell Reports, 32(4). https://doi.org/10.1016/j.celrep.2020.107957 Cite
Investigators showed MHC-I-restricted control of murine cytomegalovirus (MCMV) infection in vivo that was NK cell dependent. Using mice lacking specific Ly49 receptors, they showed that control of MCMV required inhibitory Ly49 receptors and an inhibitory signaling motif and the capacity for MCMV to downregulate MHC-I.
6445212 M6BUKB5N items 1 apa default asc 1
Scientists found that IL-2C targeting cells expressing IL-2 receptor beta caused an acute decrease in cellularity of Peyer’s Patches while cell numbers in the lamina propria and intraepithelial lymphocytes were unaffected.
High-resolution single-cell methods have revealed abnormalities in the tolerance mechanisms of several disorders and provided further insight into the B cells responsible for autoantibody production
[Cellular & Molecular Immunology]
Although both caspase-1 and caspase-11 could cleave gasdermin D in macrophages and neutrophils, researchers found that NLRC4-activated caspase-1 triggered pyroptosis in macrophages, but this pathway did not trigger pyroptosis in neutrophils.