lymphoid cells

[Cell Genomics] Investigators mapped genetic regulation of gene expression and chromatin activity in regulatory T cells and identified 133 colocalizing loci with immune disease variants.

[Nature Immunology] Researchers developed a genetic-tracing approach, termed the DivisionRecorder, that reported the extent of past proliferation of cell pools in vivo.

[Twist Bioscience Corporation] Twist Bioscience Corporation and MediSix Therapeutics announced a collaboration to discover novel antibodies against five undisclosed targets. Twist will leverage its proprietary Library of Libraries to discover five novel antibodies directed against MediSix’s targets.

[Shenzhen Pregene Biopharma Co. Ltd (Cision US, Inc.)] Shenzhen Pregene Biopharma and CellPoint announced an exclusive license agreement for the development and commercialization of PRG-1801, Pregene's single domain antibody-based anti-BCMA chimeric antigen receptor (CAR) T cell program, for the treatment of hematological indications in Europe and the United States.

[Immunity] Scientists assessed affinity and neutralization potency against the Omicron variant of several hundred naturally expressed memory B cell-derived monoclonal IgG antibodies from vaccinated COVID-19-recovered and -naïve individuals.

[Nature Methods] The authors presented receptor-antigen pairing by targeted retroviruses, which combined viral pseudotyping and molecular engineering approaches to enable one-pot library-on-library interaction screens by displaying antigens on the surface of lentiviruses and encoding their identity in the viral genome.