lymphoid cells

[Experimental Hematology] Recent findings have shown the critical roles of signal-transducing adaptor protein (STAP)-2 in B cell progenitor cells in marrow under hematopoietic stress and STAP-1 and -2 in BCR-ABL-transduced leukemogenesis. In this review, the authors focus on the role of STAPs in the bone marrow.

[Matter] Investigators developed tetrameric and dodecameric forms of a multifunctional and extensible category of high-avidity CAR-staining reagents: antigen multimers.

[Molecular Therapy-Oncolytics] For establishing a novel hinge derived from human CD34, researchers systematically tested CD34 fragments of different lengths, all containing the binding site of the QBend-10 monoclonal antibody, in a FMC63-based CD19 CAR lentiviral construct.

[Journal of the American Chemical Society] The authors reported a cell capture DNA network containing polyvalent multimodules for the specific isolation and in situ incubation of T lymphocytes.

[Cell Reports] Scientists examined the role of miR-29 in neonatal and adult CD8+ T cells, which expressed different amounts of miR-29 only prior to infection and adopt profoundly different fates after immune challenge.

[Science Immunology] Scientists showed that activation of the WNT/β-catenin signaling pathway contributed to the development of a noninflamed tumor microenvironment in tumors with high tumor mutation burden.