lymphoid cells

[Scientific Reports] In cellular models of Philadelphia Chromosome-positive B-ALL, mTOR kinase inhibitors that inhibit both mTOR-complex-1and mTOR-complex-2 enhanced the cytotoxicity of tyrosine kinase inhibitors such as dasatinib.

[Breast Cancer Research and Treatment] The authors examine the role of immune-activating cells, including tumour-infiltrating lymphocytes, and natural killer cells, as well as immune inhibitory cells, including T regulatory cells, and myeloid-derived suppressor cells in the breast cancer tumour microenvironment.

[Endocrine-Related Cancer] Investigators discuss the diverse roles of MUC4 in tumor progression and metastasis, and propose that intervening in MUC4 intercellular interactions with binding partners on blood-borne aggregating cells could potentially thwart breast cancer metastatic efficiency.

[Journal of the American Heart Association] The percentage of Tregs in the spleen, blood, and brain was detected using flow cytometry, and the number of Tregs in the ischemic hemisphere was counted using transgenic mice with an enhanced green fluorescent protein‐tagged Foxp3.

[Aging Cell] Scientists discuss how the risk factors for Alzheimer's disease (AD), particularly Apolipoprotein E, Aβ, α-secretase, β-secretase, γ-secretase, Tau, and neuroinflammation, modulate T-cell activation and the association between T cells and pathological AD hallmarks.

[Nature] Researchers showed that discoidin domain receptor 1 (DDR1), a collagen receptor with tyrosine kinase activity, instigated immune exclusion by promoting collagen fiber alignment.