Tag results:
lymphoid cells
Human Immunology News
High-Grade Serous Ovarian Tumor Cells Modulate NK Cell Function to Create an Immune-Tolerant Microenvironment
[Cell Reports] Researchers applied mass cytometry and uncover decidual-like natural killer cell subpopulations in newly diagnosed high-grade serous carcinoma samples that correlated with both tumor and transitioning epithelial-mesenchymal cell abundance.
Human Immunology News
Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity
[Cancer Immunology Research] To identify epigenetic regulators of tumor antigen expression, scientists established a transplantable syngeneic tumor model of immune escape with silenced antigen expression and used this system as a platform for a CRISPR-Cas9 suppressor screen for genes encoding epigenetic modifiers.
Immune Regulation News
Dendritic Cell Functions in the Inductive and Effector Sites of Intestinal Immunity
[Mucosal Immunology] Investigators summarize recent findings related to intestinal dendritic cells in steady state and upon inflammation, with a special focus on their functional specializations, highly dependent on their microenvironment.
Immune Regulation News
Myeloid Cell-Based Delivery of IFN-γ Reprograms the Leukemia Microenvironment and Induces Anti-Tumoral Immune Responses
[EMBO Molecular Medicine] The authors employed gene transfer into hematopoietic stem and progenitor cells to selectively express anti-tumoral cytokines in tumor-infiltrating monocytes/macrophages.
Cell Therapy News
The Immunostimulatory RNA RN7SL1 Enables CAR-T Cells to Enhance Autonomous and Endogenous Immune Function
[Cell] Investigators engineered CAR-T cells to deliver RN7SL1, an endogenous RNA that activates RIG-I/MDA5 signaling. RN7SL1 promoted expansion and effector-memory differentiation of CAR-T cells.
Cell Therapy News
UCLA Scientists Receive $1 Million Translational Award to Advance CAR T Cell Therapy for Rare Melanomas
[UCLA Newsroom] Scientists Dr. Cristina Puig-Saus and Dr. Daniel Shin from the UCLA Jonsson Comprehensive Cancer Center have received a $1 million Translational Research Award from the US Department of Defense Melanoma Research Program to help advance the use of chimeric antigen receptor, or CAR, T cell therapy as a treatment for people with acral, mucosal and uveal melanomas.