TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice

The single deletion of tumor necrosis factor receptor (TNFR) 1 induced subclinical colonic epithelial dysfunction and mucosal immune abnormalities, including accumulation of neutrophils and depletion of B cells.
[Cell Reports]
Liu, C. Y., Tam, S. S., Huang, Y., Dubé, P. E., Alhosh, R., Girish, N., Punit, S., Nataneli, S., Li, F., Bender, J. M., Washington, M. K., & Polk, D. B. (2020). TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108275 Cite
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Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation

Scientists demonstrated that apoptosis induced by JQ1 was solely attributed to the pro-apoptotic protein Bim. Conversely, cell-cycle regulation by JQ1 was associated with multiple Myc-associated gene targets.
[Cell Reports]
Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation: Cell Reports. (n.d.). Retrieved October 23, 2020, from https://www.cell.com/cell-reports/fulltext/S2211-1247(20)31279-1 Cite
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Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance

To determine if Hhex was intrinsically required throughout NK cell development or for NK cell function, scientists generated mice that specifically lacked Hhex in NK cells.
[Cell Reports]
Goh, W., Scheer, S., Jackson, J. T., Hediyeh-Zadeh, S., Delconte, R. B., Schuster, I. S., Andoniou, C. E., Rautela, J., Degli-Esposti, M. A., Davis, M. J., McCormack, M. P., Nutt, S. L., & Huntington, N. D. (2020). Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108285 Cite
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High-Throughput Continuous-Flow Microfluidic Electroporation of mRNA Into Primary Human T Cells for Applications in Cellular Therapy Manufacturing

Scientists present a microfluidic continuous-flow electrotransfection device designed for precise, consistent, and high-throughput genetic modification of target cells in cellular therapy manufacturing applications.
[Scientific Reports]
High-throughput continuous-flow microfluidic electroporation of mRNA into primary human T cells for applications in cellular therapy manufacturing | Scientific Reports. (n.d.). Retrieved October 22, 2020, from https://www.nature.com/articles/s41598-020-73755-0 Cite
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Quantitative PCR Methodology With a Volume-Based Unit for the Sophisticated Cellular Kinetic Evaluation of Chimeric Antigen Receptor T Cells

Researchers established a novel qPCR methodology incorporating a spike-in calibration curve that expressed cellular kinetics in units of copies/μL blood, as is the case for conventional pharmacokinetic studies of small molecules and other biologics.
[Scientific Reports]
Yamamoto, S., Matsumoto, S., Goto, A., Ugajin, M., Nakayama, M., Moriya, Y., & Hirabayashi, H. (2020). Quantitative PCR methodology with a volume-based unit for the sophisticated cellular kinetic evaluation of chimeric antigen receptor T cells. Scientific Reports, 10(1), 17884. https://doi.org/10.1038/s41598-020-74927-8 Cite
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HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis

Scientists characterized the immunopeptidomes of the two HLA-DR15 allomorphs DR2a and DR2b of human primary B cells and monocytes, thymus, and multiple sclerosis brain tissue.
[Cell]
Wang, J., Jelcic, I., Mühlenbruch, L., Haunerdinger, V., Toussaint, N. C., Zhao, Y., Cruciani, C., Faigle, W., Naghavian, R., Foege, M., Binder, T. M. C., Eiermann, T., Opitz, L., Fuentes-Font, L., Reynolds, R., Kwok, W. W., Nguyen, J. T., Lee, J.-H., Lutterotti, A., … Martin, R. (2020). HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis. Cell, 0(0). https://doi.org/10.1016/j.cell.2020.09.054 Cite
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A Trispecific Killer Engager Molecule Against CLEC12A Effectively Induces NK-Cell Mediated Killing of AML Cells

To target acute myeloid leukemia blasts and leukemic stem cells using natural killer (NK) cells, scientists developed a trispecific killer engager molecule containing a humanized anti-CD16 heavy chain camelid single-domain antibody that activates NK cells.
[Leukemia]
Arvindam, U. S., van Hauten, P. M. M., Schirm, D., Schaap, N., Hobo, W., Blazar, B. R., Vallera, D. A., Dolstra, H., Felices, M., & Miller, J. S. (2020). A trispecific killer engager molecule against CLEC12A effectively induces NK-cell mediated killing of AML cells. Leukemia, 1–11. https://doi.org/10.1038/s41375-020-01065-5 Cite
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Irreversible Electroporation Plus Allogenic Vγ9Vδ2 T Cells Enhances Antitumor Effect for Locally Advanced Pancreatic Cancer Patien

Researchers investigated the antitumor efficacy of irreversible electroporation plus allogeneic γδ T cells in locally advanced pancreatic cancer patients.
[Signal Transduction and Targeted Therapy]
Lin, M., Zhang, X., Liang, S., Luo, H., Alnaggar, M., Liu, A., Yin, Z., Chen, J., Niu, L., & Jiang, Y. (2020). Irreversible electroporation plus allogenic Vγ9Vδ2 T cells enhances antitumor effect for locally advanced pancreatic cancer patients. Signal Transduction and Targeted Therapy, 5(1), 1–9. https://doi.org/10.1038/s41392-020-00260-1 Cite
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T Cell Regeneration after Immunological Injury

The authors focus on the causes and consequences of impaired adaptive immunity and discuss therapeutic strategies that can recover immune function, with a particular emphasis on approaches that can promote a diverse repertoire of T cells through de novo T cell formation.
[Nature Reviews Immunology]
Velardi, E., Tsai, J. J., & van den Brink, M. R. M. (2020). T cell regeneration after immunological injury. Nature Reviews Immunology, 1–15. https://doi.org/10.1038/s41577-020-00457-z Cite
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Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

By analyzing more than 500 monoclonal antibodies (mAbs) derived from B cells induced by numerous influenza virus vaccines and infections, we found mAbs targeting conserved neutralizing influenza virus hemagglutinin epitopes were polyreactive.
[Immunity]
Guthmiller, J. J., Lan, L. Y.-L., Fernández-Quintero, M. L., Han, J., Utset, H. A., Bitar, D. J., Hamel, N. J., Stovicek, O., Li, L., Tepora, M., Henry, C., Neu, K. E., Dugan, H. L., Borowska, M. T., Chen, Y.-Q., Liu, S. T. H., Stamper, C. T., Zheng, N.-Y., Huang, M., … Wilson, P. C. (2020). Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.10.005 Cite
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Unbiased Screens Show CD8+ T Cells of COVID-19 Patients Recognize Shared Epitopes in SARS-CoV-2, Most of which Are Not Located in the Spike Protein

Scientists used an unbiased, genome-wide screening technology to determine the precise peptide sequences in SARS-CoV-2 that are recognized by the memory CD8+ T cells of COVID-19 patients.
[Immunity]
Ferretti, A. P., Kula, T., Wang, Y., Nguyen, D. M. V., Weinheimer, A., Dunlap, G. S., Xu, Q., Nabilsi, N., Perullo, C. R., Cristofaro, A. W., Whitton, H. J., Virbasius, A., Olivier, K. J., Buckner, L. R., Alistar, A. T., Whitman, E. D., Bertino, S. A., Chattopadhyay, S., & MacBeath, G. (2020). Unbiased screens show CD8+ T cells of COVID-19 patients recognize shared epitopes in SARS-CoV-2, most of which are not located in the Spike protein. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.10.006 Cite
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