Tag Archives: lymphoid cells

Follicular Helper T Cell Profiles Predict Response to Costimulation Blockade in Type 1 Diabetes

Unbiased bioinformatics analysis identified that inducible costimulatory molecule (ICOS)+ folliular helper T cells and other ICOS+ populations, including peripheral helper T cells, were highly sensitive to costimulation blockade.
[Nature Immunology]
Edner, N. M., Heuts, F., Thomas, N., Wang, C. J., Petersone, L., Kenefeck, R., Kogimtzis, A., Ovcinnikovs, V., Ross, E. M., Ntavli, E., Elfaki, Y., Eichmann, M., Baptista, R., Ambery, P., Jermutus, L., Peakman, M., Rosenthal, M., & Walker, L. S. K. (2020). Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-020-0744-z Cite
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Single-Cell Atlas of Colonic CD8+ T Cells in Ulcerative Colitis

Scientists compiled an unbiased atlas of human colonic CD8+ T cells in health and ulcerative colitis using single-cell transcriptomics with T-cell receptor repertoire analysis and mass cytometry.
[Nature Medicine]
Corridoni, D., Antanaviciute, A., Gupta, T., Fawkner-Corbett, D., Aulicino, A., Jagielowicz, M., Parikh, K., Repapi, E., Taylor, S., Ishikawa, D., Hatano, R., Yamada, T., Xin, W., Slawinski, H., Bowden, R., Napolitani, G., Brain, O., Morimoto, C., Koohy, H., & Simmons, A. (2020). Single-cell atlas of colonic CD8 + T cells in ulcerative colitis. Nature Medicine, 1–11. https://doi.org/10.1038/s41591-020-1003-4 Cite
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LW-213 Induces Cell Apoptosis in Human Cutaneous T-cell Lymphomas by Activating PERK–eIF2α–ATF4–CHOP Axis

Researchers showed that LW-213 dose-dependently inhibited human cutaneous T-cell lymphoma cell lines with IC50 values of around 10 μM, meanwhile it potently inhibited primary leukemia cells derived from peripheral blood of T-cell lymphoma patients.
[Acta Pharmacologica Sinica]
Yu, X., Zhu, M., Wang, J., Li, H., Hu, P., Qing, Y., Wang, X., Wang, H., Wang, Z., Xu, J., Guo, Q., & Hui, H. (2020). LW-213 induces cell apoptosis in human cutaneous T-cell lymphomas by activating PERK–eIF2α–ATF4–CHOP axis. Acta Pharmacologica Sinica, 1–11. https://doi.org/10.1038/s41401-020-0466-7 Cite
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FDA Approves Monjuvi® (Tafasitamab-cxix) in Combination with Lenalidomide for the Treatment of Adult Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL)

MorphoSys AG and Incyte announced that the FDA has approved Monjuvi in combination with lenalidomide for the treatment of adult patients with relapsed or refractory DLBCL not otherwise specified, including DLBCL arising from low grade lymphoma, and who are not eligible for autologous stem cell transplant.
[MorphoSys AG]
Press Release

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Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

Researchers examined how regulation and function of gene products that provide the target epitopes for CD8+ T cell anti-tumor immunity influence therapeutic efficacy and resistance.
[Immunity]
Effern, M., Glodde, N., Braun, M., Liebing, J., Boll, H. N., Yong, M., Bawden, E., Hinze, D., Boorn-Konijnenberg, D. van den, Daoud, M., Aymans, P., Landsberg, J., Smyth, M. J., Flatz, L., Tüting, T., Bald, T., Gebhardt, T., & Hölzel, M. (2020). Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.07.007 Cite
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A Nanoscale Metal Organic Frameworks-Based Vaccine Synergises with PD-1 Blockade to Potentiate Anti-Tumor Immunity

Scientists designed an ultrafast, low-temperature, and universal self-assembly route to integrate immunology-associated large molecules into metal-organic-framework-gated mesoporous silica as cancer vaccines.
[Nature Communications]
Li, X., Wang, X., Ito, A., & Tsuji, N. M. (2020). A nanoscale metal organic frameworks-based vaccine synergises with PD-1 blockade to potentiate anti-tumour immunity. Nature Communications, 11(1), 3858. https://doi.org/10.1038/s41467-020-17637-z Cite
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A Novel Transgenic Mouse Strain Expressing PKCβII Demonstrates Expansion of B1 and Marginal Zone B Cell Populations

Researchers investigated the relative role of PKCβII in B cells by generating transgenic mice where expression of the transgene is directed to these cells using the Eµ promoter
[Scientific Reports]
Azar, A. A., Michie, A. M., Tarafdar, A., Malik, N., Menon, G. K., Till, K. J., Vlatković, N., & Slupsky, J. R. (2020). A novel transgenic mouse strain expressing PKCβII demonstrates expansion of B1 and marginal zone B cell populations. Scientific Reports, 10(1), 13156. https://doi.org/10.1038/s41598-020-70191-y Cite
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Metabolic Conditioning of CD8+ Effector T Cells for Adoptive Cell Therapy

Investigators showed that transient glucose restriction in activated CD8+ effector T cells metabolically primed effector functions and enhanced tumor clearance in mice.
[Nature Metabolism]
Klein Geltink, R. I., Edwards-Hicks, J., Apostolova, P., O’Sullivan, D., Sanin, D. E., Patterson, A. E., Puleston, D. J., Ligthart, N. A. M., Buescher, J. M., Grzes, K. M., Kabat, A. M., Stanczak, M., Curtis, J. D., Hässler, F., Uhl, F. M., Fabri, M., Zeiser, R., Pearce, E. J., & Pearce, E. L. (2020). Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy. Nature Metabolism, 1–14. https://doi.org/10.1038/s42255-020-0256-z Cite
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Correlative Study of Epigenetic Regulation of Tumor Microenvironment in Spindle Cell Melanomas and Cutaneous Malignant Peripheral Nerve Sheath Tumors

Scientists investigated the epigenetic regulation of promoters and gene bodies and their effect on the tumor microenvironment composition of cutaneous malignant peripheral nerve sheath tumors and spindle cell melanomas.
[Scientific Reports]
Vougiouklakis, T., Aung, P. P., Vasudevaraja, V., Prieto, V. G., Torres-Cabala, C. A., Sulman, E. P., Snuderl, M., & Jour, G. (2020). Correlative study of epigenetic regulation of tumor microenvironment in spindle cell melanomas and cutaneous malignant peripheral nerve sheath tumors. Scientific Reports, 10(1), 12996. https://doi.org/10.1038/s41598-020-69787-1 Cite
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The Impact of Donor Type on the Outcome of Pediatric Patients with Very High Risk Acute Lymphoblastic Leukemia. A Study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG

Investigators demonstrated the impact of donor type on overall results of allogeneic stem cell transplantation for very-high risk pediatric acute lymphoblastic leukemia with worse results when using mismatched donor stem cell source.
[Bone Marrow Transplantation]
Dalle, J.-H., Balduzzi, A., Bader, P., Pieczonka, A., Yaniv, I., Lankester, A., Bierings, M., Yesilipek, A., Sedlacek, P., Ifversen, M., Svec, P., Toporski, J., Gungor, T., Wachowiak, J., Glogova, E., Poetschger, U., & Peters, C. (2020). The impact of donor type on the outcome of pediatric patients with very high risk acute lymphoblastic leukemia. A study of the ALL SCT 2003 BFM-SG and 2007-BFM-International SG. Bone Marrow Transplantation, 1–10. https://doi.org/10.1038/s41409-020-01014-x Cite
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Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

Targeting melanosomal proteins or oncogenic CDK4R24C by adoptive cell transfer of the same epitope-specific CD8+ T cells revealed diverse genetic and non-genetic immune escape mechanisms.
[Immunity]
Effern, M., Glodde, N., Braun, M., Liebing, J., Boll, H. N., Yong, M., Bawden, E., Hinze, D., Boorn-Konijnenberg, D. van den, Daoud, M., Aymans, P., Landsberg, J., Smyth, M. J., Flatz, L., Tüting, T., Bald, T., Gebhardt, T., & Hölzel, M. (2020). Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.07.007 Cite
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Overexpression of miR-382 Sensitizes Hepatocellular Carcinoma Cells to γδ T Cells through Inhibiting the Expression of C-Flip

As miR-382 was observed to be downregulated in hepatocellular carcinoma (HCC) tissues and cell lines, researchers found that overexpression of miR-382 increased the sensitivity of HCC cells to γδ T cells.
[Molecular Therapy-Oncolytics]
Chen, Z., Zheng, Z., Feng, L., Huo, Z., Huang, L., Fu, M., Chen, Q., Ke, Y., Yang, J., & Hou, B. (2020). Overexpression of miR-382 sensitizes hepatocellular carcinoma cells to γδ T cells through inhibiting the expression of c-FLIP. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.07.012 Cite
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