lymphoid cells

[Nanotechnology] Researchers designed a nanoliposome co-encapsulation of chlorin E6 and SB-3CT to realize significant antitumoral proliferation and metastasis efficacy after laser irradiation in A375 cells.

[Blood Reviews] Scientists summarize the current knowledge about statins and other agents used as endothelial protectants. They propose further studies using statins for prophylaxis and prevention of end-organ damage related to extensive endothelial dysfunction in hematopoietic stem cell transplantation and chimeric antigen receptor-T cells.

[Bone Marrow Transplantation] The ASTCT, CIBMTR, and the EBMT, jointly convened an expert panel to formulate consensus recommendations for role, timing, and sequencing of auto-, allo-hematopoietic cell transplantation, and chimeric antigen receptor T-cell therapy for patients with newly diagnosed and relapsed/refractory mantle cell lymphoma.

[Journal of Experimental Medicine] Optically clear immunocompromised zebrafish were engrafted with fluorescent-labeled human cancers along with CAR T cells, bispecific T cell engagers, and antibody peptide epitope conjugates, allowing real-time single-cell visualization of T cell–based immunotherapies in vivo.

[Cancer Cell] Researchers compared the efficacies of sequential and/or combinatorial regimens in subcutaneous murine models of melanoma driven by BrafV600, Nras, or Nf1 mutations as well as colorectal and pancreatic carcinoma driven by KrasG12C.

[Nature Immunology] By reinstating Foxp3 protein expression and suppressor function in cells expressing a reversible Foxp3 null allele in severely diseased mice, researchers found that the resulting single pool of rescued Treg cells normalized immune activation, quelled severe tissue inflammation, reversed fatal autoimmune disease and provided long-term protection against them.