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Pulmonary Cell NewsResearchers compared the efficacies of sequential and/or combinatorial regimens in subcutaneous murine models of melanoma driven by BrafV600, Nras, or Nf1 mutations as well as colorectal and pancreatic carcinoma driven by KrasG12C.
[Cancer Cell]
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Wang, Y., Liu, S., Yang, Z., Algazi, A. P., Lomeli, S. H., Wang, Y., Othus, M., Hong, A., Wang, X., Randolph, C. E., Jones, A. M., Bosenberg, M. W., Byrum, S. D., Tackett, A. J., Lopez, H., Yates, C., Solit, D. B., Ribas, A., Piva, M., … Lo, R. S. (2021). Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy. Cancer Cell, 0(0). https://doi.org/10.1016/j.ccell.2021.07.023 Cite
