Cancer-Associated POT1 Mutations Lead to Telomere Elongation without Induction of a DNA Damage Response

The authors tested the effects of CAS9‐engineered caPOT1 mutations in human embryonic and hematopoietic stem cells.
[EMBO Journal]
Kim, W.-T., Hennick, K., Johnson, J., Finnerty, B., Choo, S., Short, S. B., Drubin, C., Forster, R., McMaster, M. L., & Hockemeyer, D. (2021). Cancer-associated POT1 mutations lead to telomere elongation without induction of a DNA damage response. The EMBO Journal, n/a(n/a), e107346. https://doi.org/10.15252/embj.2020107346 Cite
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

0
Share

ITIH5, a p53-Responsive Gene, Inhibits the Growth and Metastasis of Melanoma Cells by Downregulating the Transcriptional Activity of KLF4

Scientists found that the expression of ITIH5 was decreased in melanoma tissues compared with normal skin tissues.
[Cell Death & Disease]
Liu, J., Cao, F., Li, X., Zhang, L., Liu, Z., Li, X., Lin, J., & Han, C. (2021). ITIH5, a p53-responsive gene, inhibits the growth and metastasis of melanoma cells by downregulating the transcriptional activity of KLF4. Cell Death & Disease, 12(5), 1–15. https://doi.org/10.1038/s41419-021-03707-7 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Volar Location and Degree of Pigmentation Are Associated with Poor Survival and First Metastasis Pattern in Acral Melanoma

Researchers evaluated patient demographics, stages, clinicopathological features, anatomic site of melanoma including nail versus volar surface, and degree of melanoma pigmentations, sentinel lymph node biopsy results, and the first metastasis sites.
[Pigment Cell & Melanoma Research]
Ryu, G. W., Choi, Y. D., Jin, S., Chung, I.-J., Shin, M.-H., & Yun, S. J. (n.d.). Volar location and degree of pigmentation are associated with poor survival and first metastasis pattern in acral melanoma. Pigment Cell & Melanoma Research, n/a(n/a). https://doi.org/https://doi.org/10.1111/pcmr.12983 Cite
Abstract
Bookmark

No account yet? Register

0
Share

BNIP3 Promotes HIF-1α-Driven Melanoma Growth by Curbing Intracellular Iron Homeostasis

Scientists found that BNIP3‐deprived melanoma cells displayed increased intracellular iron levels caused by heightened NCOA4‐mediated ferritinophagy, which fostered PHD2‐mediated HIF‐1α destabilization.
[EMBO Journal]
Vara-Pérez, M., Rossi, M., Van den Haute, C., Maes, H., Sassano, M. L., Venkataramani, V., Michalke, B., Romano, E., Rillaerts, K., Garg, A. D., Schepkens, C., Bosisio, F. M., Wouters, J., Oliveira, A. I., Vangheluwe, P., Annaert, W., Swinnen, J. V., Colet, J. M., van den Oord, J. J., … Agostinis, P. (2021). BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis. The EMBO Journal, n/a(n/a), e106214. https://doi.org/10.15252/embj.2020106214 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Advances in Targeting Cutaneous Melanoma

[Cancers]
Kasakovski, D., Skrygan, M., Gambichler, T., & Susok, L. (2021). Advances in Targeting Cutaneous Melanoma. Cancers, 13(9), 2090. https://doi.org/10.3390/cancers13092090 Cite
Full Article
Bookmark

No account yet? Register

0
Share

SynNotch CAR Circuits Enhance Solid Tumor Recognition and Promote Persistent Antitumor Activity in Mouse Models

Researchers improved the specificity and persistent antitumor activity of therapeutic T cells with synthetic Notch CAR circuits.
[Science Translational Medicine]
Hyrenius-Wittsten, A., Su, Y., Park, M., Garcia, J. M., Alavi, J., Perry, N., Montgomery, G., Liu, B., & Roybal, K. T. (2021). SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models. Science Translational Medicine, 13(591). https://doi.org/10.1126/scitranslmed.abd8836 Cite
Full Article
Bookmark

No account yet? Register

0
Share

Inhibition of Post-surgery Tumour Recurrence via a Hydrogel Releasing CAR-T Cells and Anti-PDL1-Conjugated Platelets

Researchers showed that the release, through the implantation of a hyaluronic acid hydrogel, of CAR-T cells targeting the human chondroitin sulfate proteoglycan 4, polymer nanoparticles encapsulating the cytokine interleukin-15 and platelets conjugated with the checkpoint inhibitor programmed death-ligand 1 into the tumor cavity of mice with a resected subcutaneous melanoma tumour inhibits the local recurrence of the tumor.
[Nature Biomedical Engineering]
Hu, Q., Li, H., Archibong, E., Chen, Q., Ruan, H., Ahn, S., Dukhovlinova, E., Kang, Y., Wen, D., Dotti, G., & Gu, Z. (2021). Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets. Nature Biomedical Engineering, 1–10. https://doi.org/10.1038/s41551-021-00712-1 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Reprogramming the Anti-tumor Immune Response via CRISPR Genetic and Epigenetic Editing

The basis for development, mechanism of action and outcomes from recently published Cas9-based clinical trial (genetic editing) and dCas9/Cas13-based pre-clinical (epigenetic editing) data are discussed.
[Molecular Therapy-Methods & Clinical Development]
Alves, E., Taifour, S., Dolcetti, R., Chee, J., Nowak, A. K., Gaudieri, S., & Blancafort, P. (2021). Reprogramming the anti-tumor immune response via CRISPR genetic and epigenetic editing. Molecular Therapy - Methods & Clinical Development, 0(0). https://doi.org/10.1016/j.omtm.2021.04.009 Cite
AbstractGraphical Abstract
Bookmark

No account yet? Register

+1
Share

Heme Catabolism by Tumor-Associated Macrophages Controls Metastasis Formation

Scientists showed that a distinct subset of tumor-associated macrophages, endowed with high rates of heme catabolism by the stress-responsive enzyme heme oxygenase-1, played a critical role in shaping a prometastatic tumor microenvironment favoring immunosuppression, angiogenesis and epithelial-to-mesenchymal transition.
[Nature Immunology]
Consonni, F. M., Bleve, A., Totaro, M. G., Storto, M., Kunderfranco, P., Termanini, A., Pasqualini, F., Alì, C., Pandolfo, C., Sgambelluri, F., Grazia, G., Santinami, M., Maurichi, A., Milione, M., Erreni, M., Doni, A., Fabbri, M., Gribaldo, L., Rulli, E., … Sica, A. (2021). Heme catabolism by tumor-associated macrophages controls metastasis formation. Nature Immunology, 1–12. https://doi.org/10.1038/s41590-021-00921-5 Cite
Abstract
Bookmark

No account yet? Register

0
Share

Multifunctionality of CD8+ T Cells and PD-L1 Expression as a Biomarker of Anti-PD-1 Antibody Efficacy in Advanced Melanoma

Scientists evaluated multi‐cytokine production and immune exhaustion of peripheral CD8+ T cells in melanoma patients treated with anti‐PD‐1 antibodies.
[Journal of Dermatology]
Manabe, K., Yamasaki, O., Nakagawa, Y., Miyake, T., Udono, H., & Morizane, S. (n.d.). Multifunctionality of CD8+ T cells and PD-L1 expression as a biomarker of anti-PD-1 antibody efficacy in advanced melanoma. The Journal of Dermatology, n/a(n/a). https://doi.org/https://doi.org/10.1111/1346-8138.15904 Cite
Abstract
Bookmark

No account yet? Register

0
Share

LINC00470 Accelerates the Proliferation and Metastasis of Melanoma through Promoting APEX1 Expression

Scientists investigated the role of LINC00470 in the development of melanoma.
[Cell Death & Disease]
Huang, T., Wang, Y.-J., Huang, M.-T., Guo, Y., Yang, L.-C., Liu, X.-J., Tan, W.-Y., & Long, J.-H. (2021). LINC00470 accelerates the proliferation and metastasis of melanoma through promoting APEX1 expression. Cell Death & Disease, 12(5), 1–13. https://doi.org/10.1038/s41419-021-03612-z Cite
Full Article
Bookmark

No account yet? Register

0
Share
Share