The Melanoma Brain Metastatic Microenvironment: Aldolase C Partakes in Shaping the Malignant Phenotype of Melanoma Cells – A Case of Inter-Tumor Heterogeneity

Researchers used brain metastasizing variants from three human melanomas to explore the functional role of Aldolase C in the formation and maintenance of melanoma brain metastasis.
[Molecular Oncology]
Izraely, S., Ben‐Menachem, S., Sagi‐Assif, O., Meshel, T., Malka, S., Telerman, A., Bustos, M. A., Ramos, I. R., Pasmanik‐Chor, M., Hoon, D. S. B., & Witz, I. P. (n.d.). The melanoma brain metastatic microenvironment: Aldolase C partakes in shaping the malignant phenotype of melanoma cells - A case of inter-tumor heterogeneity. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12872 Cite
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Adipokines in the Skin and in Dermatological Diseases

Investigators provide an overview on how adipokines may integrate into the physiological conditions of the skin by introducing the cell types which are known to produce adipokines as well as the signals that target them. They also discuss data from in vivo and in vitro murine and human studies as well as genetic data on how adipokines may contribute to various aspects of the homeostasis of the skin just as to the pathogenesis of dermatological diseases.
[International Journal of Molecular Sciences]
Kovács, D., Fazekas, F., Oláh, A., & Törőcsik, D. (2020). Adipokines in the Skin and in Dermatological Diseases. International Journal of Molecular Sciences, 21(23), 9048. https://doi.org/10.3390/ijms21239048 Cite
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The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway

The anti-cancer mechanism of Isoquercitrin (IQ) against human melanoma, particularly its effect on the mitochondria-mediated apoptosis, was investigated. Treatment with IQ at 25 μM concentration effectively inhibited the proliferation of SK-MEL-2 skin cancer cells while the same concentration did not exhibit cytotoxicity against human keratinocytes HaCaT.
[Nutrients]
Won, Y.-S., Kim, J.-H., Lizardo, R. C. M., Min, H.-J., Cho, H.-D., Hong, S.-M., & Seo, K.-I. (2020). The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway. Nutrients, 12(12), 3683. https://doi.org/10.3390/nu12123683 Cite
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BH3 Mimetics Potentiate Pro-Apoptotic Activity of Encorafenib in BRAFV600E Melanoma Cells

Researchers investigated five BRAFV600E melanoma cell lines derived from drug-naïve tumor specimens to assess cell death response to encorafenib, a recently FDA-approved BRAFV600E inhibitor.
[Cancer Letters]
Hartman, M. L., Gajos-Michniewicz, A., Talaj, J. A., Mielczarek-Lewandowska, A., & Czyz, M. (2020). BH3 mimetics potentiate pro-apoptotic activity of encorafenib in BRAFV600E melanoma cells. Cancer Letters. https://doi.org/10.1016/j.canlet.2020.11.036 Cite
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Tailoring of Silica-Based Nanoporous Pod by Spermidine Multi-Activity

Spermidine bioactivity was employed for targeting tumor cell over-expressed polyamine transport system and for effective delivery of functional miRNA into melanoma cells.
[Scientific Reports]
Della Rosa, G., Di Corato, R., Carpi, S., Polini, B., Taurino, A., Tedeschi, L., Nieri, P., Rinaldi, R., & Aloisi, A. (2020). Tailoring of silica-based nanoporous pod by spermidine multi-activity. Scientific Reports, 10(1), 21142. https://doi.org/10.1038/s41598-020-77957-4 Cite
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Brain Cancer Induces Systemic Immunosuppression through Release of Non-Steroid Soluble Mediators

Researchers recapitulated the immunosuppression observed in glioblastoma patients in the C57BL/6 mouse and investigated the aetiology of low CD4 T-cell counts.
[Brain]
Ayasoufi, K., Pfaller, C. K., Evgin, L., Khadka, R. H., Tritz, Z. P., Goddery, E. N., Fain, C. E., Yokanovich, L. T., Himes, B. T., Jin, F., Zheng, J., Schuelke, M. R., Hansen, M. J., Tung, W., Parney, I. F., Pease, L. R., Vile, R. G., & Johnson, A. J. (n.d.). Brain cancer induces systemic immunosuppression through release of non-steroid soluble mediators. Brain. https://doi.org/10.1093/brain/awaa343 Cite
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uPAR-Expressing Melanoma Exosomes Promote Angiogenesis by VE-Cadherin, EGFR and uPAR Overexpression and Rise of ERK1,2 Signaling in Endothelial Cells

Investigators investigated the role of uPAR in melanoma cell lines-derived exosomes and their pro-angiogenic effects on human microvascular endothelial cells and endothelial colony-forming cells.
[Cellular and Molecular Life Sciences]
Biagioni, A., Laurenzana, A., Menicacci, B., Peppicelli, S., Andreucci, E., Bianchini, F., Guasti, D., Paoli, P., Serratì, S., Mocali, A., Calorini, L., Del Rosso, M., Fibbi, G., Chillà, A., & Margheri, F. (2020). uPAR-expressing melanoma exosomes promote angiogenesis by VE-Cadherin, EGFR and uPAR overexpression and rise of ERK1,2 signaling in endothelial cells. Cellular and Molecular Life Sciences: CMLS. https://doi.org/10.1007/s00018-020-03707-4 Cite
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Evidence for Liver and Peripheral Immune Cells Secreting Tumor-Suppressive Extracellular Vesicles in Melanoma Patients

The authors mimicked the interaction of tumor cells with liver cells and PBMC in vitro, and compared newly secreted extracellular vesicle (EV)-associated miRNAs and protein factors with those detected in melanoma patient`s plasma EV.
[Ebiomedicine]
Lee, J.-H., Eberhardt, M., Blume, K., Vera, J., & Baur, A. S. (2020). Evidence for liver and peripheral immune cells secreting tumor-suppressive extracellular vesicles in melanoma patients. EBioMedicine, 62. https://doi.org/10.1016/j.ebiom.2020.103119 Cite
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Epigenetic Regulation in the Pathogenesis of Non-Melanoma Skin Cancer

The authors discuss the recent advances in the field of epigenetics of non-melanoma skin cancer. Particularly, the role of DNA methylation, histone hyperacetylation and non-coding RNA such as long-chain noncoding RNAs, circular RNAs and miRNA in the disease progression are summarized.
[Seminars in Cancer Biology]
Kashyap, M. P., Sinha, R., Mukhtar, M. S., & Athar, M. (2020). Epigenetic Regulation in the Pathogenesis of Non-melanoma Skin Cancer. Seminars in Cancer Biology. https://doi.org/10.1016/j.semcancer.2020.11.009 Cite
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The Effect of Calcium Electroporation on Viability, Phenotype and Function of Melanoma Conditioned Macrophages

Researchers showed the effect of calcium electroporation on immune cells, using melanoma-conditioned bone marrow-derived macrophages.
[Scientific Reports]
Tremble, L. F., Heffron, C. C. B. B., & Forde, P. F. (2020). The effect of calcium electroporation on viability, phenotype and function of melanoma conditioned macrophages. Scientific Reports, 10(1), 20645. https://doi.org/10.1038/s41598-020-77743-2 Cite
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Melanoma Cells Can Be Eliminated by Sialylated CD43 × CD3 Bispecific T Cell Engager Formats In Vitro and In Vivo

To increase the efficacy of AT1413 as a therapeutic antibody, researchers generated two different formats of bispecific T-cell engaging antibodies to both CD43s and CD3ε.
[Cancer Immunology Immunotherapy]
Melanoma cells can be eliminated by sialylated CD43 × CD3 bispecific T cell engager formats in vitro and in vivo | SpringerLink. (n.d.). Retrieved November 24, 2020, from https://link.springer.com/article/10.1007/s00262-020-02780-9 Cite
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