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melanoma

PD-L1 and ICOSL Discriminate Human Secretory and Helper Dendritic Cells in Cancer, Allergy and Autoimmunity

[Nature Communications] Researchers showed, by using 16 different stimuli in vitro, that activated dendritic cells in human blood were phenotypically and functionally dichotomous, and pure cultures of type 2 conventional dendritic cells acquired these states upon appropriate stimuli.

Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Anti-Tumor T Cell Function

[Cancer Research] The authors used carbon monoxide, a short-lived gaseous molecule, to test if engaging moderate endoplasmic reticulum stress conditions could improve mitochondrial and anti-tumor functions in T cells.

Carbon Monoxide Activates PERK-Regulated Autophagy to Induce Immunometabolic Reprogramming and Boost Anti-Tumor T Cell Function

[Cancer Research] The authors used carbon monoxide, a short-lived gaseous molecule, to test if engaging moderate endoplasmic reticulum stress conditions could improve mitochondrial and anti-tumor functions in T cells.

STAG2 Regulates Interferon Signaling in Melanoma via Enhancer Loop Reprogramming

[Nature Communications] Scientists showed that depletion of stromal antigen 2 (STAG2) in melanoma cells led to the expansion of topologically associating domains and enhanced the formation of acetylated histone H3 lysine 27.

A Noncoding Regulatory RNA Gm31932 Induces Cell Cycle Arrest and Differentiation in Melanoma via the MiR-344d-3-5p/Prc1 (and Nuf2) Axis

[Cell Death & Disease] Integrative analysis of whole transcriptome sequencing data demonstrated that lncRNA-Gm31932 was significantly decreased in all-trans retinoic acid-induced and sodium 4-phenylbutanoate-induced mouse melanoma B16 cells.

Low-Metastatic Melanoma Cells Acquire Enhanced Metastatic Capability via Exosomal Transfer of MiR-199a-1-5p from Highly Metastatic Melanoma Cells

[Cell Death Discovery] Scientists showed that exosomal crosstalk between metastatic cancer cells was a new mechanism that underlied cancer metastasis and heterogeneity.

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