lymphoid cells

[Clinical Immunology] Mass cytometry and high-throughput sequencing of the T cell receptor were used to profile the host immune response to HIV-1 and P. jirovecii infection.

[Proceedings of the National Academy of Sciences of the United States of America] The authors reported that in mouse T helper 17 (Th17) cells, Stat3 phosphorylation at serine 727, required for its transcriptional activity, was carried out by homeodomain-interacting protein kinase 2 (HIPK2), a nuclear kinase selectively up-regulated in Th17 cells, but not other Th subtypes that have distinct functions in immunity.

[EMBO Journal] miPEP31 was highly expressed in Foxp3+ Tregs and significantly promoted the differentiation of Tregs without affecting their inhibitory ability.

[Molecular Therapy-Methods & Clinical Development] Researchers utilized the previously described transposase from the little brown bat, designated piggyBat, for production of CD19 specific CAR T cells.

[Nature Biotechnology] The authors described an implantable Multifunctional Alginate Scaffold for T Cell Engineering and Release that streamlined in vivo CAR-T cell manufacturing and reduced processing time to a single day.

[Experimental Hematology & Oncology] Preclinical investigation of the CD22 CAR-T therapy against B cell malignancies was evaluated by co-culturing CD22 CAR-T cells with tumor cell lines or primary blasts from patients in vitro and using a xenograft mouse model in vivo.