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lymphoid cells

Generation of Glucocorticoid-Resistant SARS-CoV-2 T Cells for Adoptive Cell Therapy

[Cell Host & Microbe] To assess the mechanisms contributing to protection, investigators analyzed humoral and T cell responses three weeks after a single BNT162b2 dose.

BATF Regulates Progenitor to Cytolytic Effector CD8+ T Cell Transition during Chronic Viral Infection

[Nature Immunology] The authors demonstrated that CX3CR1+ effector cells bear a striking similarity to short-lived effector cells during acute infection.

Tumor Microenvironment-Adjusted Prognostic Implications of the KRAS Mutation Subtype in Patients with Stage III Colorectal Cancer Treated with Adjuvant FOLFOX

[Scientific Reports] Considering the effect of KRAS mutations on tumor microenvironment, investigators analyzed the prognostic significance of KRAS mutation types after adjusting for the tumor-infiltrating lymphocytes and tumor-stromal percentage statuses.

Differential Integrin Adhesome Expression Defines Human NK Cell Residency and Developmental Stage

[Journal of Immunology] Scientists defined differences in cortical actin content associated with differential expression of actin regulating proteins, suggesting that differences in adhesome expression were associated with differences in cortical actin homeostasis.

Castration-Mediated IL-8 Promotes Myeloid Infiltration and Prostate Cancer Progression

[Nature Cancer] Scientists established a novel mechanism by which castration mediated IL-8 secretion and subsequent polymorphonuclear myeloid-derived suppressor cells infiltration.

Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Mouse Carotid Artery under Disturbed Flow

[Cell Death Discovery] Scientists investigated the heterogeneity of vascular cell populations under disturbed blood flow (d-flow). A d-flow-induced Spp1hi vascular smooth muscle cell subpopulation appeared to be endowed with osteoblast differentiation, suggesting a role in arterial stiffness.

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