lymphoid cells

[Cell] The authors detected rapid, dynamic changes in translocated microbial constituents during two years after cART initiation.

[Scientific Reports] Researchers developed bispecific antibodies for T-cell retargeting to HER3-expressing tumor cells, utilizing either a single-chain diabody format (scDb) with one binding site for HER3 and one for CD3 on T-cells or a trivalent bispecific scDb-scFv fusion protein exhibiting an additional binding site for HER3.

[Cell Reports] The authors demonstrated the applicability of high-content imaging to human T and natural killer cells and develop a pipeline for unbiased analysis of high-definition morphological profiles.

[Cell Reports] Researchers showed that serine/arginine-rich splicing factor 1, which was decreased in T cells from patients with systemic lupus erythematosus, was necessary for the homeostasis and proper function of Treg cells.

[Leukemia] Scientists utilized mass cytometry and single-cell transcriptome analysis to identify several expanded populations within the angioimmunoblastic T-cell lymphoma tumor microenvironment.

[Immunity] Scientists demonstrated that precursors of exhausted T cells sustained mitochondrial fitness, including high spare respiratory capacity, while exhausted effector T cells deteriorated metabolically over time.