lymphoid cells

[Clinical Cancer Research] Researchers investigated the combination of IL-15 with an intratumoral anti-CD40 monoclonal antibody (mAb) in a dual tumor TRAMP-C2 murine prostate cancer model and expanded the regimen to include an anti-PD-1 mAb.

[Neoplasia] Nuclear enriched abundant transcript 1 (NEAT1) depletion inhibited prostate cancer cell aerobic glycolysis accompanied by the reduction of lactate levels in the medium.

[Cell Stem Cell] The authors reported that iPSCs reprogramed from CD62L+ naive and memory T cells followed by CD19-CAR engineering and 3D-organoid system differentiation conferred products with conventional CD8αβ-positive CAR T cell characteristics.

[Journal of Hepatology] Scientists identified a proinflammatory hepatocyte subpopulation that developed primarily from periportal hepatocytes and to a lesser extent from pericentral hepatocytes and played key immunoregulatory roles in endotoxemia.

[Gut] The authors identified a group of clonotypes, characterized by semi-invariant T cell receptor alpha chains, to be significantly enriched in the blood of patients with Crohn’s disease and particularly expanded in the CD8+ T cell population.

[Cancer Immunology Research] Investigators showed that Tregs in tumor-bearing omenta predominantly had thymus-derived characteristics.