lymphoid cells

[Nature Cancer] Researchers systematically characterized the interactions between T cells and antigen-presenting myeloid cells within the tumor microenvironment and found that CD4+PD-1+CXCL13+ T cells were a major interacting hub with antigen-presenting cells in the tumor microenvironment of human non-small cell lung carcinoma.

[Therapeutic Advances in Hematology] Investigators provided an overview for the available management strategies for relapsed mantle cell lymphoma (MCL) and examines the role of CAR T cell in the current and future treatment of MCL.

[Nature Medicine] Investigators reported the results of the open-label, non-randomized part B of a Phase II trial in which they evaluated the safety and immunogenicity of a booster injection of 50 µg of the COVID-19 vaccine mRNA-1273 in 344 adult participants immunized 6–8 months earlier with a primary series of two doses of 50 µg or 100 µg of mRNA-1273.

[Open Biology] Researchers developed a CD8+ T cell and adult stem cell liver organoid system using a microfluidic chip to coculture 3D human liver organoids embedded in extracellular matrix with HLA-matched primary human T cells in suspension.

[Biochemical Pharmacology] Investigators summarize recent progress in relevant studies regarding the physiological and pathophysiological functions of MALT1, post-translational modifications of MALT1 and its role in B cell- and T cell- related diseases.

[Journal of Reproductive Immunology] Investigators hypothesized that decidual leukocytes were altered by maternal SARS-CoV-2 infection in pregnancy and that this decidual immune response was shaped by the timing of infection during gestation.