lymphoid cells

[Science Translational Medicine] Reduced-intensity conditioning for HLA-haploidentical hematopoietic cell transplantation was augmented with same-donor memory-like natural killer (NK) cells on day +7 and 3 weeks of N-803 to treat patients with relapsed/refractory AML in a clinical trial.

[Blood] As BCL2 was an important determinant of survival of both myeloid progenitor and B cells, researchers investigated whether clinical and molecular abnormalities arise in the myeloid compartment during long-term continuous venetoclax treatment of chronic lymphocytic leukemia in 89 patients.

[Bone Marrow Transplantation] Scientists investigated whether gilteritinib, a selective FLT3 inhibitor, could enhance graft-versus-leukemia effects against FLT3 internal tandem duplication mutant transfected Ba/F3 leukemia in mice.

[Molecular Therapy] Investigators treated three children suffering from severe, therapy-refractory GvHD with polyclonally expanded regulatory T cells generated from the original stem cell donor.

[ACS Nano] A rabies virus glycoprotein (RVG)-camouflaged gold yarnball that could boost the targeting efficiency at a brain tumor via dual hierarchy- and RVG-mediated spinal cord transportation, facilitating the decrease of tumor heterogeneity for T cell infiltration, was developed.

[Cell Reports] Scientists found that proteasomal activity generated multiple length variants of KK10, which bound TAP and human leukocyte antigen-B∗27:05.