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lymphoid cells
Immune Regulation News
PTPN2 Elicits Cell Autonomous and Non–Cell Autonomous Effects on Antitumor Immunity in Triple-Negative Breast Cancer
[Science Advances] Scientists explored the therapeutic potential of targeting PTPN2 in TNBC and T cells. PTPN2-deficiency in TNBC associated with T cell infiltrates and PD-L1 expression, whereas low PTPN2 associated with improved survival.
Immune Regulation News
Local Inhibition of TGF-β1 Signaling Improves Th17/Treg Balance but Not Joint Pathology during Experimental Arthritis
[Scientific Reports] Murine splenocytes were differentiated into T helper 17 cells, and the effect of the TGF-βRI inhibitor SB-505124 was studied.
Mesenchymal Cell News
Effect of HO-1-Modified BMMSCs on Immune Function in Liver Transplantation
[Scientific Reports] Researchers examined whether haem oxygenase-1 (HO-1) could enhance the immunosuppressive effects of bone marrow MSCs (BMMSCs) on the rejection of transplanted liver allografts in rats.
Immunology of Infectious Disease News
Protective Immune Trajectories in Early Viral Containment of Non-Pneumonic SARS-CoV-2 Infection
[Nature Immunology] Researchers combined a multi-omics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associated specific immune trajectories with upper airway viral containment.
Immune Regulation News
A Trispecific Antibody Targeting HER2 and T Cells Inhibits Breast Cancer Growth via CD4 Cells
[Nature] Scientists demonstrated that a trispecific antibody to HER2, CD3 and CD28 stimulated regression of breast cancers in a humanized mouse model through a mechanism involving CD4-dependent inhibition of tumor cell cycle progression.
Immune Regulation News
Regulation of Tissue-Resident Memory T Cells by the Microbiota
[Mucosal Immunology] Investigators hypothesize that memory responses to antigens from the microbiota must be ‘licensed’ by inflammatory signals activated by invasion of the host by microorganisms.