lymphoma

[International Journal of Cardiology] Researchers revealed that programmed cell death 5 (Pdcd5) deficiency attenuated cardiac aging by reducing cellular senescence and apoptosis, and increasing Parkin-mediated mitophagy, likely through p53.

[Molecular Therapy-Methods & Clinical Development] Cell-free DNA isolated from 74 blood samples of 12 patients during lymphoma treatment with the anti-CD19 CAR-T cell product axicabtagene ciloleucel were analyzed.

[Phytotherapy Research] Researchers explored the apoptotic mechanism of Moracin D in prostate cancer cells in association with peroxisome proliferator-activated receptor gamma (PPAR-γ)-related signaling involved in lipid metabolism.

[Precigen, Inc.] Precigen, Inc. announced that the US FDA has cleared the Investigational New Drug (IND) application to initiate the Phase I/Ib clinical trial of PRGN-3007 in advanced receptor tyrosine kinase-like orphan receptor 1-positive (ROR1+) hematological and solid tumors.

[Cell Reports] Scientists reported that lymphoma caused severe high endothelial venules (HEVs) regression in mouse models that phenocopied aggressive human B cell lymphomas, and that HEV dedifferentiation occurred as a consequence of a disrupted lymph-carrying conduit system.

[Blood] The authors performed whole-genome sequencing of 150 adult T cell leukemia/lymphoma (ATL) cases and revealed the overarching landscape of genetic alterations in ATL.