macrophages

[Experimental and Molecular Medicine] Investigators found that CU06-1004, as a vascular leakage blocker, could improve cardiac function by inhibiting cardiac microvascular endothelial cells' hyperpermeability and subsequently reducing the neutrophil’s plugging and infiltration in infarcted hearts.

[Journal of Clinical Investigation] Scientists investigated the role of macrophage LC3-associated phagocytosis within the bone marrow microenvironment of acute myeloid leukemia.

[Hepatology] Scientists identified interferon regulatory factor (IRF8) as an important prognostic biomarker in hepatocellular carcinoma patients which predicted the response and sensitivity to anti-PD-1 therapy.

[International Journal of Stem Cells] The protein expression of AKT, mTOR, p-AKT and p-mTOR was detected using western blot assay. The results showed that human umbilical cord mesenchymal stem cells treatment prominently promoted the glucocorticoid-induced the decrease of the collagen level and the increase of TRAP positive cells.

[Cellular & Molecular Immunology] The authors provided evidence to support the function of KLF14, a novel Krüppel-like transcription factor, in the regulation of glycolysis and the immune function of macrophages during sepsis.

[Cellular & Molecular Immunology] Investigators showed that ACE2-overexpressing A549 cell-derived microparticles were a potential therapeutic agent against SARS-CoV-2 infection.