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macrophages

Lung Type II Alveolar Epithelial Cells Collaborate with CCR2+ Inflammatory Monocytes in Host Defense against Poxvirus Infection

[Nature Communications] The authors reported that vaccinia C7 was a crucial virulence factor that blocked activation of the transcription factor IRF3.

Reduced Protection of RIPK3-Deficient Mice against Influenza by Matrix Protein 2 Ectodomain Targeted Active and Passive Vaccination Strategies

[Cell Death & Disease] The authors observed that the protection against IAV after active vaccination with matrix protein 2 ectodomain viral antigen was lost was Ripk3−/− mice.

Kinetics of LYVE-1-Positive M2-Like Macrophages in Developing and Repairing Dental Pulp In Vivo and Their Pro-Angiogenic Activity In Vitro

[Scientific Reports] Enforced expression of Lyve1 in RAW264.7 cells resulted in increased mRNA expression of matrix metalloproteinase 2 (Mmp2), Mmp9, and VEGF A. Lyve1-expressing macrophages promoted the migration and tube formation of HUVECs.

Tissue-Resident FOLR2+ Macrophages Associate with CD8+ T Cell Infiltration in Human Breast Cancer

[Cell] The authors identified a discrete population of FOLR2+ tissue-resident macrophages in healthy mammary gland and breast cancer primary tumors.

Cell-Free Extracts from Human Fat Tissue with a Hyaluronan-Based Hydrogel Attenuate Inflammation in a Spinal Cord Injury Model through M2 Microglia/Microphage Polarization

[Small] Fat extract (FE) is a cell-free liquid component containing a variety of cytokines extracted from human fat tissue using mechanical methods. A biocompatible hyaluronan and methylcellulose loaded with FE is used to treat a model of spinal cord contusion in mice.

The Pancreatic Cancer Immune Tumor Microenvironment Is Negatively Remodeled by Gemcitabine While TGF-β Receptor plus Dual Checkpoint Inhibition Maintains Antitumor Immune Cells

[Molecular Carcinogenesis] Scientists hypothesized that TGF-β receptor inhibition may alter Pancreatic ductal adenocarcinoma progression and antitumor immunity in the tumor microenvironment.

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