malaria

[Nature Communications] Scientists elucidated crystal structures, binding affinities and kinetics, and in vivo protection of eight anti-NANP antibodies derived from an RTS,S Phase IIa trial and encoded by three different heavy-chain germline genes.

[Cell Reports] Researchers used single-cell RNA sequencing to examine the diversity of both antigen-specific and total B cells in healthy subjects and malaria-exposed individuals.

[Trends in Parasitology] Recent bioengineering approaches allow for the generation of 3D microvessels and organ-specific vasculature that provide precise control of vessel architecture and flow dynamics, and hold great promise for malaria research.

[EMBO Journal] To understand specific host conditions that affect infectivity, the authors studied Plasmodium falciparum parasite liver stage development in relation to the metabolic heterogeneity of fresh human hepatocytes.

[Malaria Journal] Malaria infection in the collected maternal peripheral, placental, umbilical cord samples was determined microscopically, and ELISA was used to measure the plasma levels IL-4, IL-6, IL-10, IL-17A, and INF γ in the collected positive and negative malaria samples.

[Nature Immunology] In the presence of patient serum, γδ2 T cells phagocytosed and degraded opsonized infected red blood cells in a CD16-dependent manner, decreasing parasite multiplication.