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e.g. organoids

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mass spectrometry

Pancreatic Cell News

Rhoifolin from Plumula Nelumbinis Exhibits Anti-cancer Effects in Pancreatic Cancer via AKT/JNK Signaling Pathways

[Scientific Reports] Cell viability assay revealed that apiin, rhoifolin, and vitexin could inhibit proliferation of PANC-1 and ASPC-1, with rhoifolin showing the maximum inhibitory effect.
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Neural Cell News

Class I HDAC Overexpression Promotes Temozolomide Resistance in Glioma Cells by Regulating RAD18 Expression

[Cell Death & Disease] Researchers reported on the novel mechanism whereby overexpressed class I histone deacetylases increase the resistance of glioblastoma cells to the SN1 methylating agent temozolomide.
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Mammary Cell News

Hypoxia-Induced circWSB1 Promotes Breast Cancer Progression through Destabilizing p53 by Interacting with USP10

[Molecular Cancer] The authors investigated the expression profile of circular RNAs in breast cancer MCF-7 cells under hypoxia and normoxia using microarray.
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Endothelial Cell News

Intratumoral Heterogeneity of MYC Drives Medulloblastoma Metastasis and Angiogenesis

[Neuro-Oncology] The authors established the relevance of interclonal cross-talk between MYC-driven and non-MYC-driven medulloblastoma cells.
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ESC & iPSC News

An Approach to Measuring Protein Turnover in Human Induced Pluripotent Stem Cell Organoids by Mass Spectrometry

[Methods] Scientists designed a workflow to reproducibly extract proteins from brain organoids, measure global turnover using mass spectrometry, and statistically investigate turnover differences between genotypes.
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Hematopoiesis News

Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD-Driven AML

[Cancer Research] The authors established cells with acquired resistance to the allosteric SHP2 inhibitor SHP099 from two FLT3-ITD-positive AML cell lines.
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