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mass spectrometry

Mechanistic Study of lncRNA UCA1 Promoting Growth and Cisplatin Resistance in Lung Adenocarcinoma

[Cancer Cell International] Scientists explored the mechanism of lncRNA urothelial carcinoma-associated 1 (UCA1) promoting cisplatin resistance in lung adenocarcinoma. The UCA1 expression level in LUAD cell lines was detected by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR).

Evaluate the Presentation of Mutant KRAS Peptides on Individual HLA-I Molecules Using Targeted Mass Spectrometry and Identify 13 Unpublished KRASG12C/D/R/V Mutation/HLA-I Pairs and Nine...

[Cell Reports Methods] The authors evaluated the presentation of mutant KRAS peptides on individual HLA-I molecules using targeted mass spectrometry and identify 13 unpublished KRASG12C/D/R/V mutation/HLA-I pairs and nine previously described pairs.

Systematic Discovery and Validation of T Cell Targets Directed against Oncogenic KRAS Mutations

[Cell Reports Methods] The authors evaluated the presentation of mutant KRAS peptides on individual HLA-I molecules using targeted mass spectrometry and identify 13 unpublished KRASG12C/D/R/V mutation/HLA-I pairs and nine previously described pairs.

Low Temperature Plasma Irradiation Products of Sodium Lactate Solution That Induce Cell Death on U251SP Glioblastoma Cells Were Identified

[Scientific Reports] Scientists quantified several major chemical products, such as pyruvate, formate, and acetate, in plasma-activated L-sodium lactate solution by nuclear magnetic resonance analysis.

Paraquat-Induced Cholesterol Biosynthesis Proteins Dysregulation in Human Brain Microvascular Endothelial Cells

[Scientific Reports] Researchers unraveled biological mechanisms associated to the exposure of 1, 10 and 100 µM of Paraquat for 24 hours on human brain microvascular endothelial cells.

Analytical Approaches to Assess Metabolic Changes in Psoriasis

[Journal of Pharmaceutical and Biomedical Analysis] Psoriasis is known to alter the expression of proteins that are involved in the inflammatory and antioxidant response, as well as protein biosynthesis, degradation, as well as cell proliferation and apoptosis.

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