melanoma

[European Journal of Pharmacology] Investigators established chemo-resistant melanoma cells and found that expression of stemness genes were upregulated in the resistant melanoma cells. And Astragalus polysaccharide could downregulate expression of stemness genes.

[Cell Reports] Researchers investigated immune-related targets of SOX10 and observed positive regulation of herpesvirus entry mediator and carcinoembryonic-antigen cell-adhesion molecule 1.

[Science Signaling] Scientists studied the role of YAP/TAZ signaling in endothelial cells (ECs) in tumor angiogenesis and found that the expression of YAP/TAZ and downstream target genes in ECs correlated with tumor vascularization in human colorectal carcinomas and skin melanoma.

[The Melanoma Research Alliance] The Melanoma Research Alliance (MRA) welcomes the US FDA decision to expand eligibility of Merck’s Keytruda to include patients with Stage IIB and IIC melanoma.

[Scientific Reports] Researchers showed that increasing NTF2 expression in WM983B metastatic melanoma cells reduced cell proliferation and motility while increasing apoptosis. They also demonstrated that increasing NTF2 expression in these cells significantly inhibited metastasis and prolonged survival of mice.

[Journal of Investigative Dermatology] The authors investigated the role of NUMB in melanoma progression and its regulatory mechanism. Analysis of The Cancer Genome Atlas melanoma datasets revealed that high NUMB expression in melanoma tissues correlated with improved patient survival.