melanoma

[Journal of Biomedical Science] The role of Receptor tyrosine kinase-like orphan receptor 2 (ROR2) in tumor growth was assessed in xenotransplantation experiments followed by immunohistochemistry analysis of the tumors.

[Highlight Therapeutics, Inc.] Highlight Therapeutics, Inc.announced positive preliminary results of a Phase II study of intratumoral administration of BO-112 with pembrolizumab in patients with advanced melanoma whose disease had progressed on first-line anti-PD1-based therapy.

[Nature] Investigators showed that dietary palmitic acid, but not oleic acid or linoleic acid, promoted metastasis in oral carcinomas and melanoma in mice. Tumor-associated Schwann cells secreted a specialized proregenerative ECM, the ablation of which inhibited metastasis initiation.

[Cell Death & Disease] The authors detected a higher concentration of CD73+ tumor-derived extracellular vesicles enriched in exosomes in central and peripheral body fluids of glioblastoma patients than in those of patients with other brain tumors.

[Chemico-Biological interactions] The authors found that 1,3-diphenyl-2-benzyl-1,3-propanedione (DPBP) had high in vitro antineoplastic activity against murine B16F10 melanoma cells and used transdermal and topical formulations of DPBP to evaluate its activity in a murine model of melanoma.

[Cell Death Discovery] The abundance of myeloid-derived suppressor cells in the tumour microenvironment was associated with therapeutic efficacy and disease outcome. Scientists analyzed the changes in the immune contexture in response to the carbon ion treatment.