melanoma

[Nature Communications] The authors integrated spatially resolved transcriptomics, single-cell RNA-seq, and single-nucleus RNA-seq to characterize tumor-microenvironment interactions at the tumor boundary, and identified a distinct “interface” cell state where the tumor contacted neighboring tissues.

[Cell Death & Disease] The PERK pathway inhibits global protein synthesis while allowing translation of specific mRNAs, such as the ATF4 transcription factor.

[Cell Death & Disease] The authors identified the role of p32 in the malignancy of both murine and human melanoma and found that p32 knockdown led to reduced cell proliferation, migration, and invasion in murine and human melanoma cells.

[Cancer Research] Researchers showed that testosterone promotes melanoma proliferation by activating ZIP9 (SLC39A9), a zinc transporter that is widely expressed in human melanoma but not intentionally targeted by available therapeutics.

[Cell Death Discovery] Investigators found that proteasome 26 S subunit ATPase 2 (PSMC2) was significantly upregulated in skin cutaneous melanoma (SKCM) patients from The Cancer Genome Atlas datasets and verified in clinical SKCM tissues.

[Drug Discovery Today] Scientists provide a concise overview of the main principles and potential of cell tracking, followed by a discussion of the clinically relevant labeling strategies and their application in adoptive T cell therapies (ACT).